The Chemokine Receptor (CCR) family is a part of the G protein-coupled receptor (GPCR) family, including various members such as CCR1 to CCR10. These receptors possess seven transmembrane domains and are primarily expressed on immune cells such as T cells, B cells, and macrophages, regulating cell directional movement, inflammatory responses, and immune surveillance. CCRs, upon binding to specific chemokines, activate signaling pathways such as PI3K/Akt, ERK/MAPK, participating in cell chemotaxis, survival, and proliferation. Gene-specific expression is associated with various inflammatory and autoimmune diseases, while mutations or dysregulation in expression may contribute to increased susceptibility or accelerated progression of diseases.