Inhibitors/Agonists Metabolic Enzyme Dehydrogenase

Dehydrogenase

Dehydrogenases constitute a crucial enzyme family extensively involved in intracellular redox reactions, including lactate dehydrogenase, and pyruvate dehydrogenase, among others. These enzymes typically consist of multiple subunits and possess specific cofactors such as NAD+ or FAD to facilitate electron transfer. Dehydrogenases exhibit diverse cellular localization, such as within mitochondria or the cytoplasm, and are essential for energy metabolism and cellular respiration. They participate in various metabolic pathways like glycolysis, the citric acid cycle, and fatty acid oxidation, while also playing significant roles in signaling pathways. Specificity in gene expression and mutations affecting dehydrogenase function can lead to metabolic imbalances or diseases, with certain genetic disorders being associated with mutations in dehydrogenase genes.