Chemistry Heterocyclic Building Blocks Pyrimidines dibromopyrimidine
Dibromopyrimidine derivatives can participate in cross-coupling reactions, such as Suzuki-Miyaura coupling or Heck coupling, to form carbon-carbon bonds with aryl or vinyl halides in the presence of suitable catalysts. These reactions are important in the synthesis of biaryl compounds and functionalized aromatic molecules.
Dibromopyrimidine can be utilized as a building block for the synthesis of various heterocyclic compounds, including fused heterocycles and complex organic molecules. These heterocycles are significant in medicinal chemistry and can be used as pharmaceuticals, agrochemicals, and materials.
Dibromopyrimidine can be synthesized through various methods, typically involving the bromination of pyrimidine or its derivatives. The bromination reaction usually employs brominating agents such as bromine or N-bromosuccinimide (NBS) in the presence of a suitable solvent or catalyst.
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4,5-Dibromo-6-(trifluoromethyl)pyrimidine
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4,6-Dibromo-2-(trifluoromethyl)pyrimidine