Inhibitors/Agonists Ubiquitin DUB

DUB

DUBs (Deubiquitinating enzymes) are a class of enzymes specialized in removing ubiquitin tags from proteins, thereby finely regulating protein stability and function. The DUB family comprises about 100 enzymes, divided into several subfamilies primarily based on differences in their catalytic domains' structures. These enzymes are widely distributed throughout the cell compartments, including the cytoplasm, nucleus, and membrane systems, and participate in numerous biological processes, including protein degradation, signal transduction, cell cycle control, and DNA repair. The tissue-specific gene expression of DUBs, as well as abnormalities in their activity and expression levels, are closely associated with various diseases, including cancer, neurodegenerative diseases, and immune system disorders. Research on DUBs reveals their critical roles in maintaining cellular homeostasis and health.