Epigenetic reader proteins are responsible for recognizing and binding specific epigenetic marks, such as methylated histones or DNA, influencing chromatin structure and gene expression. Family members include domain proteins like Bromo, Chromo, PHD, Tudor, etc. These proteins are located in the cell nucleus and participate in various biological processes, such as DNA repair, transcription activation or repression, by recognizing specific epigenetic modifications. They exhibit specific expression patterns in different types of cells or tissues and are associated with various biological functions and disease processes. Mutations or dysregulation of specific family members are closely linked to health issues such as cancer and neurodegenerative diseases, revealing their crucial roles in cellular functions and diseases.