FAK (Focal Adhesion Kinase) is a non-receptor tyrosine kinase, with key members including FAK and Pyk2. They consist of a FERM domain, a tyrosine kinase domain, and a lipid-binding region, primarily localized at cell-extracellular matrix contact points, regulating cell adhesion, migration, proliferation, and survival. Through interaction with integrins and other extracellular proteins, FAK activates downstream signaling pathways such as PI3K/Akt and MAPK. FAK is expressed in various cell types, and its activity and expression levels are regulated during tumorigenesis, cardiovascular diseases, and cell migration processes. The specific expression and mutations of the FAK gene are associated with disease progression, making it a target for therapeutic research.