The FATP family consists of fatty acid transport proteins, including members such as FATP1 to FATP6, mainly involved in the uptake and metabolism of long-chain and very-long-chain fatty acids. These proteins have long-chain fatty acyl-CoA synthetase activity and are located on the cell membrane, crucial for lipid metabolism and energy production. FATP is expressed in various tissues, such as the liver, muscle, heart, and adipose tissue. They participate in regulating glucose metabolism and fatty acid oxidation through activating the AMPK and PI3K/Akt signaling pathways. Genetic mutations affecting FATP functions are closely associated with metabolic diseases like obesity, type 2 diabetes, and cardiovascular diseases.