FLT3 (Fms-related tyrosine kinase 3) is a member of the class III receptor tyrosine kinase family, primarily composed of an extracellular ligand-binding domain, a transmembrane region, and an intracellular tyrosine kinase domain. Positioned on the surface of blood cells, particularly expressed in hematopoietic stem cells and progenitor cells, FLT3 activates multiple signaling pathways such as PI3K/AKT and RAS/MAPK by binding to its ligand FL, thereby participating in the regulation of cell proliferation, differentiation, and survival. The expression of the FLT3 gene is tissue-specific, and its mutations (such as internal tandem duplication (ITD) and D835 point mutations) are closely associated with the pathogenesis of hematological diseases such as acute myeloid leukemia (AML), making it a therapeutic target for related diseases.