Inhibitors/Agonists Protein Tyrosine Kinase/RTK HER2

HER2

HER2 (Human Epidermal Growth Factor Receptor 2) is one of the members of the ERBB family, which includes EGFR, HER2, HER3, and HER4. The structure of HER2 comprises extracellular ligand-binding domains, a transmembrane domain, and an intracellular tyrosine kinase domain. It can be activated without a ligand and is primarily expressed in epithelial cells such as those in the breast and stomach. It participates in cell proliferation and differentiation signaling by forming homodimers or heterodimers. Overexpression or amplification of HER2 is common in certain cancers such as breast cancer and is associated with poor prognosis. Its signaling pathways include PI3K/AKT and MAPK, affecting tumor growth and survival.