Chemistry Organic Building Blocks Hydrazones
Hydrazones are a type of organic compounds characterized by the presence of the structure R1R2C=N−NH2. They share similarities with ketones and aldehydes, but instead of the oxygen =O group, they have a =N−NH2 functional group.
Hydrazine, as well as its derivatives such as organohydrazines and 1,1-diorganohydrazines, are capable of undergoing reactions with aldehydes and ketones to form hydrazones.
Hydrazones serve as a fundamental component in bioconjugation strategies.
Typically, hydrazones are synthesized through the reaction of hydrazine with ketones or aldehydes, leading to the replacement of the oxygen atom with the hydrazine moiety.
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tert-Butyl 2-(4-(pyridin-2-yl)benzylidene)hydrazinecarboxylate
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2-(1-Phenylethylidene)hydrazinecarbothioamide
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(Z)-2-(2-(2-Chlorophenyl)hydrazineylidene)-3-oxo-N-phenylbutanamide
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N-(4-(2-(3,5-Diamino-4H-pyrazol-4-ylidene)hydrazinyl)phenyl)acetamide
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(Z)-Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
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2,2,2-Trifluoro-N'-(piperazin-2-ylidene)acetohydrazide
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Ethyl 2-Chloro-2-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)hydrazono)acetate
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3-((2,2-Diphenylhydrazono)methyl)-9-ethyl-9H-carbazole
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Calcium 3-hydroxy-4-((4-methyl-2-sulfonatophenyl)diazenyl)-2-naphthoate
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N,N-Dibenzyl-4-((2,2-diphenylhydrazono)methyl)aniline