Chemistry Organic Building Blocks Hydrazones
Hydrazones are a type of organic compounds characterized by the presence of the structure R1R2C=N−NH2. They share similarities with ketones and aldehydes, but instead of the oxygen =O group, they have a =N−NH2 functional group.
Hydrazine, as well as its derivatives such as organohydrazines and 1,1-diorganohydrazines, are capable of undergoing reactions with aldehydes and ketones to form hydrazones.
Hydrazones serve as a fundamental component in bioconjugation strategies.
Typically, hydrazones are synthesized through the reaction of hydrazine with ketones or aldehydes, leading to the replacement of the oxygen atom with the hydrazine moiety.
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2,3-Dichloro-4-(2-(3-chloro-4-fluorophenyl)hydrazono)but-2-enoic acid
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2-Ethyl-5-(2-phenylhydrazono)furan-3,4(2H,5H)-dione
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(2-(Trifluoromethoxy)phenyl)carbonohydrazonoyl dicyanide
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2-(2-Hydroxy-3-methoxybenzylidene)hydrazinecarboxamide
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(3,5-Bis(trifluoromethyl)phenyl)carbonohydrazonoyl dicyanide
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(Z)-2-(2-(2-Chlorophenyl)hydrazineylidene)-3-oxo-N-phenylbutanamide
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2-(2-Hydroxy-3-methoxybenzylidene)hydrazinecarbothioamide
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3-Hydrazono-3,4,5,6,7,8-hexahydroquinoxalin-2(1H)-one
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2-Hydroxy-6-methyl-3-(1-(2-phenylhydrazono)ethyl)-4H-pyran-4-one
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2,4-Dichloro-6-(1-hydrazono-2-(2,4,6-trichlorophenyl)ethyl)phenyl 2-fluorobenzoate
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N-(3,4-Dichlorophenyl)-2-oxo-2-(2-(3,4,5-trimethoxybenzylidene)hydrazinyl)acetamide
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2-(2-Benzylidenehydrazinyl)-4-methyl-4,5-dihydrooxazole