Chemistry Heterocyclic Building Blocks Indazoles

Indazoles

Indazole, which is also known as isoindazole, is an aromatic heterocyclic organic compound. It is composed of the fusion of benzene and pyrazole, resulting in a bicyclic structure.

An amphoteric molecule, indazole can undergo protonation to form an indazolium cation or deprotonation to form an indazolate anion.

The equilibrium between indazolium cation and indazole has a corresponding pKa value of 1.04, while the equilibrium between indazole and indazolate anion has a pKa value of 13.86.

The indazole derivatives, due to their potent pharmacological activity, have been under investigation in the pharmaceutical field for various therapeutic uses, such as, antibacterial, anticancer, antionidants, anti-inflammatory, antidiabetic, antiviral, atniproliferative, antituberculosis, antispermetogenic activity, and antipsychotic drugs.

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Framework+−

(1H-indazol-4-yl)boronic acid (1H-indazol-6-yl)boronic acid 1-(1H-indazol-1-yl)ethan-1-one 1-(tetrahydro-2H-pyran-2-yl)-1H-indazole 1-benzyl-1H-indazole 1-ethyl-1H-indazole 1H-indazol-3-amine 1H-indazol-3-ol 1H-indazol-4-amine 1H-indazol-4-ol 1H-indazol-5-amine 1H-indazol-6-amine 1H-indazol-6-ol 1H-indazol-7-amine 1H-indazole-3-carbaldehyde 1H-indazole-3-carbonitrile 1H-indazole-3-carboxylic acid 1H-indazole-4-carboxylic acid 1H-indazole-5-carboxylic acid 1H-indazole-7-carboxylic acid 2,3-dimethyl-2H-indazole 2-methyl-2H-indazole 3-(piperidin-4-yl)-1H-indazole 3-chloro-1H-indazole 4,5,6,7-tetrahydro-1H-indazole 4-chloro-1H-indazole 4-fluoro-1H-indazole 4-methoxy-1H-indazole 4-methyl-1H-indazole 4-nitro-1H-indazole 5-bromo-1H-indazole 5-chloro-1H-indazole 5-methoxy-1H-indazole 5-nitro-1H-indazole 6-(trifluoromethyl)-1H-indazole 6-bromo-1H-indazole 6-chloro-1H-indazole 6-fluoro-1H-indazole 6-methoxy-1H-indazole 6-methyl-1H-indazole 6-nitro-1H-indazole 7-bromo-1H-indazole 7-chloro-1H-indazole 7-fluoro-1H-indazole 7-methoxy-1H-indazole 7-nitro-1H-indazole methyl 1H-indazole-3-carboxylate methyl 1H-indazole-4-carboxylate methyl 1H-indazole-5-carboxylate methyl 1H-indazole-6-carboxylate methyl 1H-indazole-7-carboxylate methyl 2-methyl-2H-indazole-3-carboxylate tert-butyl 1H-indazole-1-carboxylate

By Key Group+−

amino-indazole amino-indazole-carboxylate bromo-ethyl-indazole bromo-fluoro-indazole bromo-indazol-amine bromo-indazole bromo-indazole-carboxylate bromo-methoxy-indazole bromo-nitro-indazole bromoindazole-carboxylic-acid bromoisopropyl-indazole bromomethyl-indazole chlorindazolamide chlorindazole-carboxylic-acid chloro-indazole chloro-indazole-amine chloro-indazole-carboxylate chloro-methyl-indazole dimethyl-indazole dioxaborolan-indazole dioxaborolane-indazole-carboxylate fluoro-indazol-amine fluoro-indazole-carboxylate fluoro-indazole-carboxylic-acid fluoro-methyl-indazole indazo-piperazine indazol-amine indazol-boronic acid indazol-one indazolamide-bromide indazole-benzene indazole-carbonitrile indazole-carboxylate indazole-carboxylic acid indazole-hydrochloride indazole-hydroxyl indazole-methanol indazole-piperidine-carboxylate iodo-indazol-amine iodo-indazole iodo-indazole-carboxylate iodomethyl-indazole methoxy-indazole-carboxylate methoxyindazole-carboxylic-acid methyl-indazol-amine methyl-indazolamide methyl-indazole-carboxylic-acid methyl-nitro-indazole methylindazole nitro-indazol-amide nitro-indazol-amine tetrahydropyran-indazole trifluoromethyl-indazole

By Parent Nucleus+−

Aliphatic Heterocycles Aromatic Heterocycles Imidazoles Other Aliphatic Heterocycles Other Aromatic Heterocycles Piperazines Piperidines Pyrazoles Pyridines Pyrimidines Pyrrolidines Tetrahydropyrans

By Functional Group+−

Alcohols Aldehydes Aliphatic Chain Hydrocarbons Aliphatic Cyclic Hydrocarbons Alkenyls Alkyls Alkynyls Amides Amines Aryls Benzyl bromides Bromides Carboxylic Acids Chiral Building Blocks Chlorides Esters Ethers Fluorinated Building Blocks Iodides Ketones Nitriles Nitroes Oximes Phenols Phosphoruses Sulfamides Sulfides Sulfonates Sulfonic Acids Trifluoromethyls

By Chemical Elements+−

    Bx
    Cx
    Nx
    Ox
    Fx
    Six
    Px
    Sx
    Clx
    Brx
    Ix

    Formula Weight+−

    cLogP+−

    H-Acceptors+−

    H-Donors+−

    Polar Surface Area+−

    Druglikeness+−

    NNCH/NNH+−

    sp3-Atoms+−

    Non-Aromatic Rings+−

    Aromatic Rings+−

    Rotatable Bonds+−

    3-Bromo-7-fluoro-1H-indazole

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    A3369901257853-72-797%

    3-Bromo-7-fluoro-1H-indazole

    $445.00/5g

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    Methyl 5-chloro-1H-indazole-6-carboxylate

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    A3049151227269-07-997%

    Methyl 5-chloro-1H-indazole-6-carboxylate

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    1-Methyl-1H-indazol-6-ol

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    A163110118933-92-998%

    1-Methyl-1H-indazol-6-ol

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    4-Bromo-7-methoxy-1H-indazole

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    A593140938062-01-298%

    4-Bromo-7-methoxy-1H-indazole

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    (1,3-Dimethyl-1H-indazol-7-yl)boronic acid

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    A6623911309982-19-198+%

    (1,3-Dimethyl-1H-indazol-7-yl)boronic acid

    $179.00/100mg

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    5-Amino-3-methyl-1H-indazole

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    A10949090764-90-297%

    5-Amino-3-methyl-1H-indazole

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    4-Chloro-5-nitro-1H-indazole

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    A231103907958-42-397+%

    4-Chloro-5-nitro-1H-indazole

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    (1-Methyl-1H-indazol-6-yl)methanol

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    A1195821092961-10-898%

    (1-Methyl-1H-indazol-6-yl)methanol

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    (5-Methyl-1H-indazol-6-yl)boronic acid

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    A6442621310383-42-697%

    (5-Methyl-1H-indazol-6-yl)boronic acid

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    6-Hydroxy-1H-indazole-5-carboxylic acid

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    A555870574758-53-595%

    6-Hydroxy-1H-indazole-5-carboxylic acid

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    7-(Benzyloxy)-1H-indazole

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    A105143351210-09-897%

    7-(Benzyloxy)-1H-indazole

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    1-(1-Methyl-1H-indazol-6-yl)ethanone

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    A5267821159511-25-795%

    1-(1-Methyl-1H-indazol-6-yl)ethanone

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    Methyl 5,6-difluoro-1H-indazole-3-carboxylate

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    A845406885279-01-695%

    Methyl 5,6-difluoro-1H-indazole-3-carboxylate

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    5-Iodo-6-methyl-1H-indazole

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    A2956511034154-15-897%

    5-Iodo-6-methyl-1H-indazole

    $244.00/5g

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    tert-Butyl 4-amino-1H-indazole-1-carboxylate

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    A768042801315-74-298%

    tert-Butyl 4-amino-1H-indazole-1-carboxylate

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    6-Nitro-1H-indazole-3-carbaldehyde

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    A153112315203-37-398%

    6-Nitro-1H-indazole-3-carbaldehyde

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    3-Bromo-4-fluoro-1H-indazole

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    A476994885521-60-898%

    3-Bromo-4-fluoro-1H-indazole

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    Ethyl 2-(1H-indazol-1-yl)acetate

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    A1141774954116-84-895%

    Ethyl 2-(1H-indazol-1-yl)acetate

    $117.00/100mg

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    Adavivint

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    A5910201467093-03-397%

    Adavivint

    $136.00/10mg

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    4-Bromo-7-chloro-1H-indazole

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    A2272991186334-61-195%

    4-Bromo-7-chloro-1H-indazole

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