Chemistry Heterocyclic Building Blocks Isoquinolines
Isoquinoline is an organic compound that belongs to the heterocyclic aromatic class. This compound is a structural isomer of quinoline, and both of them are classified as benzopyridines, which consist of a pyridine ring fused to a benzene ring.
At temperatures higher than its melting point, isoquinoline is a hygroscopic liquid that is colorless and has a sharp and unpleasant odor.
Isoquinoline, which is an analog of pyridine, exhibits weak basicity with a pKa value of 5.14. When treated with strong acids, like HCl, it undergoes protonation to produce salts. Moreover, it also forms adducts with Lewis acids, such as BF3.
Isoquinolines find various applications in industry such as the production of dyes, paints, insecticides, and antifungals. They are also utilized as a solvent for extracting resins and terpenes and serve as a corrosion inhibitor.
Isoquinoline can be described as a benzopyridine that is ortho-fused heteroarene, with its nitrogen atom not being directly attached to the benzene ring.
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(2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)boronic acid
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tert-Butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate
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6-(Trifluoromethyl)isoquinolin-4-amine
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2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-oxoacetic acid