Chemistry Heterocyclic Building Blocks Isothiazoles

Isothiazoles

An organic compound that has a five-membered aromatic ring consisting of three carbon atoms, one nitrogen atom, and one sulfur atom is known as an isothiazole or 1,2-thiazole.

Liquids or low-melting-point solids are typical physical states of isothiazoles and benzisothiazoles, but the presence of polar substituents can elevate their melting points due to hydrogen bonding and other interactions.

Isothiazole belongs to a group of chemicals called azoles, wherein the two heteroatoms are located adjacent to each other, distinguishing it from its isomeric form, thiazole.

Isothiazoles belong to the category of five-membered sulfur heterocycles, which are of great importance. Due to the presence of two electronegative heteroatoms in a 1,2-relationship, isothiazoles have unique properties that make them widely used in medicinal chemistry and organic synthesis.

Isothiazole, a colorless liquid that is mobile and has a boiling point of 114.1°C and a density of 1.352, emits an odor reminiscent of pyridine. Although it is sparingly soluble in water, it serves as an effective solvent for numerous organic substances. However, caution is necessary when handling isothiazole since it is more toxic than pyridine.

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benzo[d]isothiazol-3(2H)-one 1,1-dioxide benzo[d]isothiazole isothiazole

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benzoisothiazol bromoisothiazolo isothiazole-amine isothiazole-carboxylic acid methylisothiazole

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    Isothiazole-5-carboxylic acid

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    A10839310271-85-997%

    Isothiazole-5-carboxylic acid

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    (4aR,7S,8aR)-9,9-Dimethyltetrahydro-4H-4a,7-methanobenzo[c][1,2]oxazireno[2,3-b]isothiazole 3,3-dioxide

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    A163833104372-31-897%

    (4aR,7S,8aR)-9,9-Dimethyltetrahydro-4H-4a,7-methanobenzo[c][1,2]oxazireno[2,3-b]isothiazole 3,3-dioxide

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    2-(4-(Dimethylamino)phenyl)benzo[d]isothiazol-3(2H)-one

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    A1453017106595-93-197%

    2-(4-(Dimethylamino)phenyl)benzo[d]isothiazol-3(2H)-one

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    (R)-tert-Butyl 4-(tert-butyl)-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide

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    (R)-tert-Butyl 4-(tert-butyl)-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide

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    5-Nitroisothiazole-3-carboxylic acid

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    5-Nitroisothiazole-3-carboxylic acid

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    5-Amino-3-methylisothiazole Hydrochloride

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    5-Amino-3-methylisothiazole Hydrochloride

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    3-Methoxybenzo[d]isothiazole 1,1-dioxide

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    3-Methoxybenzo[d]isothiazole 1,1-dioxide

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    2-(Benzo[d]thiazol-2-ylmethyl)benzo[d]isothiazol-3(2H)-one 1,1-dioxide

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    A1234831452278-67-098%

    2-(Benzo[d]thiazol-2-ylmethyl)benzo[d]isothiazol-3(2H)-one 1,1-dioxide

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    (S)-tert-Butyl 4-phenyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide

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    A856051479687-23-598%

    (S)-tert-Butyl 4-phenyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide

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    Isothiazol-5-amine hydrochloride

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    Isothiazol-5-amine hydrochloride

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    tert-Butyl (3aR,6aS)-tetrahydrocyclopenta[d][1,2,3]oxathiazole-3(3aH)-carboxylate 2,2-dioxide

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    A16005361330069-69-695%

    tert-Butyl (3aR,6aS)-tetrahydrocyclopenta[d][1,2,3]oxathiazole-3(3aH)-carboxylate 2,2-dioxide

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    3-((1,1-Dioxidobenzo[d]isothiazol-3-yl)amino)butanoic acid

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    A11398701094565-75-995%

    3-((1,1-Dioxidobenzo[d]isothiazol-3-yl)amino)butanoic acid

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    Saccharin sodium hydrate

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    A114796682385-42-097%

    Saccharin sodium hydrate

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    3-Phenylisothiazol-5-amine

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    A13170114208-52-795%

    3-Phenylisothiazol-5-amine

    $430.00/1g

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    5-Amino-3-methylisothiazole-4-carbonitrile

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    A64021741808-35-997%

    5-Amino-3-methylisothiazole-4-carbonitrile

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    (E)-1-((3aR,6S,7aS)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)but-2-en-1-one

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    A47075794594-81-797%

    (E)-1-((3aR,6S,7aS)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)but-2-en-1-one

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    rel-(4aR,7S,8aR)-9,9-Dimethyltetrahydro-4H-4a,7-methanobenzo[c][1,2]oxazireno[2,3-b]isothiazole 3,3-dioxide

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    rel-(4aR,7S,8aR)-9,9-Dimethyltetrahydro-4H-4a,7-methanobenzo[c][1,2]oxazireno[2,3-b]isothiazole 3,3-dioxide

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    Isothiazole-3-carboxylic acid

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    A1445634576-90-395%

    Isothiazole-3-carboxylic acid

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    3-(4-(Methylsulfonyl)piperazin-1-yl)benzo[d]isothiazole

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    A15022402190680-18-198%

    3-(4-(Methylsulfonyl)piperazin-1-yl)benzo[d]isothiazole

    $226.00/100mg

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    5,7-Dimethoxybenzo[d]isothiazol-3(2H)-one 1,1-dioxide

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    A48244764404-51-995%

    5,7-Dimethoxybenzo[d]isothiazol-3(2H)-one 1,1-dioxide

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