Chemistry Heterocyclic Building Blocks Isoxazoles

Isoxazoles

Isoxazole is a drug scaffold that can be used to develop new drugs with various biological activities (e.g. anti-microbial, anti-viral, anti-cancer, anti-inflammatory, immunomodulatory, anti-convulsant or anti-diabetic properties).

Isoxazoles, which are heterocycles with an N-O bond, possess aromatic properties. Due to the fragility of this bond, these heterocycles can be opened under reductive conditions. They are frequently employed as substitutes for enaminoketones or β-diketones.

Composed of nitrogen and oxygen atoms, isoxazoles form a significant category of heterocyclic compounds. They occur naturally in various products and are also synthesized for their biological applications, such as antibacterial, anti-inflammatory, and analgesic agents, as well as for their usefulness in functional materials.

An important group of five-membered aromatic heterocycles that contain two electronegative heteroatoms, nitrogen and oxygen, in a 1,2-relationship and three regular sp2 carbon atoms are known as isoxazoles.

Isoxazoles have been shown to be capable of forming hydrogen bond donor/acceptor interactions with a range of enzymes and receptors.

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(3-phenylisoxazol-5-yl)methanol 3-bromoisoxazole 3-methyl-5-phenylisoxazole 3-methylisoxazole 3-phenylisoxazol-5-amine 5-(thiophen-2-yl)isoxazole 5-cyclopropylisoxazole 5-methyl-3-phenylisoxazole 5-methylisoxazole 5-phenylisoxazole-3-carboxylic acid ethyl isoxazole-3-carboxylate ethyl isoxazole-4-carboxylate isoxazol-3-amine isoxazol-3-ylmethanol isoxazol-5-amine isoxazol-5-ylmethanol isoxazole-3-carboxylic acid isoxazole-5-carboxylic acid methyl 5-phenylisoxazole-3-carboxylate N-((5R,6R)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-6-yl)-3-phenylisoxazole-4-carboxamide

By Key Group+−

aminoisoxazole bromoisoxazole dihydroisoxazol dimethylisoxazole ethylisoxazol isoxazole isoxazole-carboxylate isoxazolecarboxylic methylisoxazole phenylisoxazole

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Aromatic Heterocycles Furans Oxadiazoles Piperidines Thiazoles Thiophenes

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Alcohols Aldehydes Alkynyls Amides Amines Aryls Benzyl bromides Benzyl Chlorides Bromides Carboxylic Acids Chiral Building Blocks Chlorides Esters Ethers Fluorinated Building Blocks Iodides Ketones Nitriles Nitroes Organoboron Phenols Sulfonyl Chlorides

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    By Configuration+−

    Ethyl 5-aminoisoxazole-4-carboxylate

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    A18920434859-64-895%

    Ethyl 5-aminoisoxazole-4-carboxylate

    $133.00/10g

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    5-Isopropyl-3-methylisoxazole-4-carboxylic acid

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    A44611990087-36-895%

    5-Isopropyl-3-methylisoxazole-4-carboxylic acid

    $988.00/5g

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    Methyl 5-(3-cyanophenyl)isoxazole-3-carboxylate

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    A116824956360-06-897%

    Methyl 5-(3-cyanophenyl)isoxazole-3-carboxylate

    $232.00/1g

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    5-Bromo-3-methylbenzo[d]isoxazole

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    A78250766033-76-998%

    5-Bromo-3-methylbenzo[d]isoxazole

    $19.00/100mg

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    6-Nitrobenzo[d]isoxazole

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    A34312739835-08-098%

    6-Nitrobenzo[d]isoxazole

    $30.00/100mg

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    Methyl 3-(3-bromophenyl)-1,2-oxazole-5-carboxylate

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    A1085445377059-68-295%

    Methyl 3-(3-bromophenyl)-1,2-oxazole-5-carboxylate

    $175.00/250mg

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    3-Phenylisoxazol-5(4H)-one

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    A6003961076-59-197%

    3-Phenylisoxazol-5(4H)-one

    $55.00/5g

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    5-(Naphthalen-2-yl)isoxazole-3-carboxylic acid

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    A10765681105193-46-195%

    5-(Naphthalen-2-yl)isoxazole-3-carboxylic acid

    $536.00/1g

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    Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate

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    A171141123770-62-795%

    Ethyl 5-(hydroxymethyl)isoxazole-3-carboxylate

    $39.00/1g

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    4-Chloro-3-methylisoxazol-5-amine

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    A616046166964-09-698%

    4-Chloro-3-methylisoxazol-5-amine

    $29.00/5g

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    5-(2-Hydroxyethyl)isoxazole-3-carboxylic acid

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    A15359911782872-85-895%

    5-(2-Hydroxyethyl)isoxazole-3-carboxylic acid

    $1074.00/1g

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    Methyl 5-(4-bromophenyl)isoxazole-3-carboxylate

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    A177315517870-15-497%

    Methyl 5-(4-bromophenyl)isoxazole-3-carboxylate

    $98.00/25g

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    1-(3-(Benzyloxy)isoxazol-5-yl)-2-bromoethanone

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    A1218259104182-22-197%

    1-(3-(Benzyloxy)isoxazol-5-yl)-2-bromoethanone

    $78.00/100mg

    Detail
    tert-Butyl 2-cyclopropyl-6-(3,5-dimethylisoxazol-4-yl)-4-(tetrahydrofuran-2-carbonyl)-1H-benzo[d]imidazole-1-carboxylate

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    A6461091637773-87-597%

    tert-Butyl 2-cyclopropyl-6-(3,5-dimethylisoxazol-4-yl)-4-(tetrahydrofuran-2-carbonyl)-1H-benzo[d]imidazole-1-carboxylate

    $189.00/100mg

    Detail
    (3,5-Dimethyl-4-isoxazolyl)methanol

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    A77575119788-36-496%

    (3,5-Dimethyl-4-isoxazolyl)methanol

    $27.00/1g

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    Diethyl 2-(((3-(3,5-dimethylisoxazol-4-yl)-4-methoxyphenyl)amino)methylene)malonate

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    A7587091300031-60-097%

    Diethyl 2-(((3-(3,5-dimethylisoxazol-4-yl)-4-methoxyphenyl)amino)methylene)malonate

    $281.00/250mg

    Detail
    CAY10603

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    A1609581045792-66-298%

    CAY10603

    $126.00/5mg

    Detail
    3-Methylisoxazole-5-carboxylic acid

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    A3918064857-42-595%

    3-Methylisoxazole-5-carboxylic acid

    $99.00/10g

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    3-Cyclopropylisoxazol-5-amine

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    A75073521080-91-198%

    3-Cyclopropylisoxazol-5-amine

    $128.00/250mg

    Detail
    5-Isopropylisoxazol-3-amine

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    A12028655809-38-695%

    5-Isopropylisoxazol-3-amine

    $249.00/250mg

    Detail
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