Home Chemistry Heterocyclic Building Blocks Indazoles Methyl 1H-Indazole-5-Carboxylate
Substitution Reactions: The carboxylate group can undergo nucleophilic substitution reactions with various electrophiles, leading to the formation of substituted carboxylates.
Esterification: The carboxylic acid group can react with alcohols to form esters under acidic conditions or with acid chlorides or anhydrides in the presence of a base.
Nucleophilic Addition: The carbon-carbon double bond in the indazole ring can undergo nucleophilic addition reactions with nucleophiles such as amines, thiols, or organometallic compounds.
Reduction: The carbonyl group can be reduced to the corresponding alcohol using reducing agents such as sodium borohydride or lithium aluminum hydride.
Oxidation: The alcohol group can be oxidized to the corresponding carboxylic acid using oxidizing agents such as potassium permanganate or chromium(VI) compounds.
Ring-closure Reactions: The compound can participate in ring-closure reactions under suitable conditions, leading to the formation of cyclic compounds or fused ring systems.
Substitution Reactions at the Indazole Ring: The indazole ring can undergo substitution reactions at the nitrogen atoms or the aromatic positions, leading to the formation of substituted indazoles.
Condensation Reactions: It can participate in condensation reactions with carbonyl compounds or other nucleophiles to form cyclic compounds or larger molecules.
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Methyl 3-bromo-1H-indazole-5-carboxylate
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