Chemistry Heterocyclic Building Blocks Morpholines
The chemical formula of morpholine is O(CH2CH2)2NH, which contains both amine and ether functional groups, making it an organic heterocycle.
Morpholine, a colorless liquid with a fishy odor, possesses a flash point of 100°F and can corrode tissue. It is less dense than water and can dissolve in water, while its vapors are denser than air.
Organic synthesis extensively employs morpholine, which serves as a fundamental component in manufacturing various compounds such as the antibiotic linezolid, the anticancer drug gefitinib (Iressa), and the analgesic dextromoramide.
Morpholine serves as a solvent for various organic compounds, including resins, dyes, and waxes. In organic synthesis, morpholine-based enamines have broad applications in the formation of C-C and C-X bonds.
Several pharmaceuticals, such as antibiotics, anticancer agents, and analgesics, are prepared using morpholines.
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(S)-2-(4-Benzylmorpholin-3-yl)acetonitrile
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(R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione
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(R)-Morpholine-2-carbonitrile hydrochloride
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N-benzyloxycarbonyl-3-fluoro-4-morpholinoaniline
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