Chemistry Organic Building Blocks Aryls N-Cyclopropylbenzamide

N-Cyclopropylbenzamide

Amide Hydrolysis: N-cyclopropylbenzamide can undergo hydrolysis in the presence of acid or base to yield N-cyclopropylbenzoic acid and the corresponding amine. Nucleophilic Substitution: The nitrogen atom in the amide group can undergo nucleophilic substitution reactions with various nucleophiles, such as alkyl or aryl Grignard reagents, to form substituted amides. Acylation: The amide nitrogen can be acylated using acylating agents, such as acyl chlorides (e.g., acetyl chloride), to produce N-acyl derivatives. Hoffmann Rearrangement: In the presence of a strong base like sodium or potassium hydroxide, N-cyclopropylbenzamide can undergo the Hoffmann rearrangement, leading to the formation of an isocyanate. Substitution Reactions: The aromatic ring can undergo electrophilic aromatic substitution reactions, such as Friedel-Crafts acylation or alkylation, when treated with appropriate reagents and catalysts. Reductive Amination: The cyclopropylamine group can be further modified through reductive amination reactions with suitable carbonyl compounds. Nucleophilic Addition to the Cyclopropyl Ring: The cyclopropyl group can undergo nucleophilic addition reactions, especially when the ring is activated by electron-withdrawing or electron-donating groups.

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