Chemistry Heterocyclic Building Blocks Piperidines
Piperidine has the molecular formula (CH2)5NH and is classified as an organic compound. This heterocyclic amine is composed of a six-membered ring that incorporates five methylene bridges (–CH2–) and one amine bridge (–NH–).
Piperidine is a clear, colorless liquid that emits a smell reminiscent of pepper. It has a lower density than water, but it can be mixed with water and will float on its surface. This liquid has a flash point of 37 °F, a melting point of -15.8 °F (-9 °C), and a boiling point of 222.8 °F (106 °C).
Piperidine, like cyclohexane, exhibits a preference for a chair conformation. However, unlike cyclohexane, piperidine displays two distinct chair conformations characterized by the N–H bond occupying either an axial or an equatorial position.
Piperidine serves both as a solvent and a base, and this is also the case for specific derivatives. For instance, N-formylpiperidine acts as a polar aprotic solvent, exhibiting superior hydrocarbon solubility when compared to other amide solvents.
Piperidine, a nitrogen-containing azacycloalkane, serves various functions including that of a reagent, a protic and non-polar solvent, a base, a catalyst, and a metabolite in both humans and plants. It is essentially a cyclohexane in which one carbon atom is substituted with a nitrogen atom.
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(S)-3-Methyl-1-(2-(piperidin-1-yl)phenyl)butan-1-amine
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2-(2,6-Dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione
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Bis(2,2,6,6-tetramethylpiperidin-4-yl) decanedioate
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(2,4-Difluorophenyl)(piperidin-4-yl)methanone oxime hydrochloride
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3-(4-Nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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1-(3-Chloropropyl)piperidine hydrochloride
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(E)-2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
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3,3-Dichloro-1-(4-nitrophenyl)piperidin-2-one