Chemistry Heterocyclic Building Blocks Piperidines
Piperidine has the molecular formula (CH2)5NH and is classified as an organic compound. This heterocyclic amine is composed of a six-membered ring that incorporates five methylene bridges (–CH2–) and one amine bridge (–NH–).
Piperidine is a clear, colorless liquid that emits a smell reminiscent of pepper. It has a lower density than water, but it can be mixed with water and will float on its surface. This liquid has a flash point of 37 °F, a melting point of -15.8 °F (-9 °C), and a boiling point of 222.8 °F (106 °C).
Piperidine, like cyclohexane, exhibits a preference for a chair conformation. However, unlike cyclohexane, piperidine displays two distinct chair conformations characterized by the N–H bond occupying either an axial or an equatorial position.
Piperidine serves both as a solvent and a base, and this is also the case for specific derivatives. For instance, N-formylpiperidine acts as a polar aprotic solvent, exhibiting superior hydrocarbon solubility when compared to other amide solvents.
Piperidine, a nitrogen-containing azacycloalkane, serves various functions including that of a reagent, a protic and non-polar solvent, a base, a catalyst, and a metabolite in both humans and plants. It is essentially a cyclohexane in which one carbon atom is substituted with a nitrogen atom.
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2-(1-(tert-Butoxycarbonyl)piperidin-4-yl)acetic acid
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tert-Butyl 4-(piperazin-1-yl)piperidine-1-carboxylate
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tert-Butyl 9-oxo-3-azaspiro[5.5]undecane-3-carboxylate
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tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate hydrochloride
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cis-1-(tert-Butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid
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tert-Butyl 4-(1-amino-2-hydroxyethyl)piperidine-1-carboxylate hydrochloride
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1-(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidin-4-one
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tert-Butyl 4-(2-ethoxy-1,1-difluoro-2-oxoethyl)piperidine-1-carboxylate
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tert-Butyl 4-(hydroxymethyl)-[1,4'-bipiperidine]-1'-carboxylate
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tert-Butyl [4,4'-bipiperidine]-1-carboxylate
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Benzyl 4-(2-hydroxyethyl)piperidine-1-carboxylate
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tert-Butyl 3,3-difluoro-4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate
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tert-Butyl 3,9-diazaspiro[5.5]undecane-3-carboxylate hydrochloride
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tert-Butyl 2-(piperidin-4-yl)acetate oxalate