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CAS No. : | 1000339-62-7 | MDL No. : | MFCD09749664 |
Formula : | C8H5BrFN | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 214.03 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In tetrahydrofuran; at -78 - 20℃; | Description for D140; 7-Bromo-6-fluoro-1H-indole (D140); To a solution of 2-bromo-3-fluoro-1 -nitrobenzene (13 g) in anhydrous THF (80 mL) was added 1 M vinylmagnesium bromide in THF (178 mL) dropwise at -78 0C slowly. Then the mixture was allowed to warm to RT and stirred for 2 hours. TLC indicated the reaction was complete. The reaction mixture was poured into saturated NH4CI solution, the organic phase was separated by extraction with EtOAc (3 * 200 mL). Purification by column chromatography afforded of 7-bromo-6-fluoro-1H-indole (D140) (3 g) as a brown oil. | |
Description for D140; 7-Bromo-6-fluoro-1H-indole (D140); To a solution of <strong>[59255-94-6]2-bromo-3-fluoro-1-nitrobenzene</strong> (13 g) in anhydrous THF (80 mL) was added 1 M vinylmagnesium bromide in THF (178 mL) dropwise at -78 C. slowly. Then the mixture was allowed to warm to RT and stirred for 2 hours. TLC indicated the reaction was complete. The reaction mixture was poured into saturated NH4Cl solution, the organic phase was separated by extraction with EtOAc (3×200 mL). Purification by column chromatography afforded of 7-bromo-6-fluoro-1H-indole (D140) (3 g) as a brown oil. |