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Chemistry
Organic Building Blocks
Aryls
2-(3-Methoxy-4-methylphenyl)acetic acid
Chemistry
Organic Building Blocks
Aryls
Ethers Carboxylic Acids Benzene Compounds

[ CAS No. 100861-38-9 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 100861-38-9
Chemical Structure| 100861-38-9
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COA NMR CNMR HPLC LC-MS

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SDS Specification
Alternatived Products of [ 100861-38-9 ]

Product Details of [ 100861-38-9 ]

CAS No. :100861-38-9 MDL No. :MFCD06208114
Formula : C10H12O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 180.20 Pubchem ID :-
Synonyms :

Safety of [ 100861-38-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 100861-38-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 100861-38-9 ]

[ 100861-38-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 64829-31-8 ]
  • [ 100861-38-9 ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; water; In ethanol; for 20h;Heating / reflux; To <strong>[64829-31-8]3-methoxy-4-methylphenyl acetonitrile</strong> (3 g, 18.63 mmol) in ethanol (100 mL) was added 20 mL of 10% aqueous NaOH solution. The reaction mixture was refluxed for 20 h. Ethanol was removed, the crude mixture was dissolved in water (100 mL) and adjusted to pH 4 by adding conc. HCl. Solids that formed were filtered, washed with water, and dried in vacuum to give 23 (2.64 g) as off white solid.1H NMR (CDCl3, 400 MHz): delta2.18 (s, 3H), 3.60 (s, 2H), 3.81 (s, 3H), 6.73-6.77 (m, 2H), 7.07 (d, 1H, J=7.6 Hz). LC/MS=180 (M+1).
EXAMPLE 2: Synthesis of Compound EK2-(3-(3-hydroxy-2,6-dimethylbenzyloxy)-4-methylphenyl)acetic acid Step A: Preparation of 2-(3-methoxy-4-methylphenyl)acetic acid: To a stirred solution of <strong>[64829-31-8]2-(3-methoxy-4-methylphenyl)acetonitrile</strong> (5g, 31mmol) in abs ethanol (25ml) was added 2M NaOH (20ml) at room temperature and reaction mixture was refluxed for 16 hours or until starting material is consumed. The reaction mixture was concentrated, diluted in chloroform and pH was adjusted to 4 by addition of IN HCl. The organic layer was washed with brine, dried over Na2S04, filtered, concentrated, to give off white solid. The solid was washed with hexane, filtered, dried under vacuum and purified by flash chromatography on a silica gel column (chloroform: methanol, 95:5) to give the title compound.*H NMR (400 MHz, CDC13): 2.19 (s, 3H); 3.62 (s, 2H); 3.82 (s, 3H); 6.74 (m, 2H); 7.14 (d, 1H).
Step A: Preparation of 2-(3-methoxy-4-methylphenyl)acetic acid:; To a stirred solution of <strong>[64829-31-8]2-(3-methoxy-4-methylphenyl)acetonitrile</strong> (5g, 31mmol) in abs ethanol (25ml) was added 2M NaOH (20ml) at room temperature and reaction mixture was re fluxed for 16 hours or until starting material is gone. The reaction mixture was concentrated, diluted in chloroform and pH was adjusted to 4 by addition of IN HCl, The organic layer was washed with brine, dried over Na2SO4, filtered, concentrated, to give off white solid. The solid was washed with hexane, filtered, dried under vacuum and purified by flash chromatography on a silica gel column (chloroform: methanol, 95:5) to give the title compound. <n="94"/>1H NMR (400 MHz, CDCl3): 2.19 (s, 3H); 3.62 (s, 2H); 3.82 (s, 3H); 6.74 (m, 3H); 7.14 (d, IH).
Reference： [1]Patent: US2007/293475,2007,A1 .Location in patent: Page/Page column 7
[2]Patent: WO2011/46800,2011,A1 .Location in patent: Page/Page column 84
[3]Patent: WO2009/151695,2009,A1 .Location in patent: Page/Page column 92-93
  • 2
  • [ 124-38-9 ]
  • [ 1706-11-2 ]
  • [ 100861-38-9 ]
Reference： [1]Journal of the American Chemical Society,2011,vol. 133,p. 1698 - 1701

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