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With palladium on activated charcoal; hydrogen In ethanol at 20℃; for 12 h;
[0553j To a solution of ethyl 3-methoxy-4-nitrobenzoate (5-B) (7.65 g, 34 mmol) in EtOH (20 mL) was added Pd/C (1.5 g), while stirring at rt under H2 for 12 h. The solid was removed by filtration and the mixture was extracted with EA. The solvent was removed to afford ethyl 4-amino-3-methoxybenzoate (5-C) (7.5 g).
Reference:
[1] European Journal of Organic Chemistry, 2010, # 24, p. 4662 - 4670
[2] Journal of Organic Chemistry, 1980, vol. 45, # 11, p. 2243 - 2246
[3] Patent: WO2014/31784, 2014, A1, . Location in patent: Paragraph 0553
With palladium on activated charcoal; hydrogen; In ethanol; at 20℃; for 12.0h;
[0553j To a solution of ethyl 3-methoxy-4-nitrobenzoate (5-B) (7.65 g, 34 mmol) in EtOH (20 mL) was added Pd/C (1.5 g), while stirring at rt under H2 for 12 h. The solid was removed by filtration and the mixture was extracted with EA. The solvent was removed to afford ethyl 4-amino-3-methoxybenzoate (5-C) (7.5 g).