Alternatived Products of [ 1036383-27-3 ]
Product Details of [ 1036383-27-3 ]
CAS No. : | 1036383-27-3 |
MDL No. : | MFCD24686437 |
Formula : |
C7H4ClFO2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
174.56
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 1036383-27-3 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 1036383-27-3 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1036383-27-3 ]
- 1
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[ 165047-23-4 ]
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[ 111-77-3 ]
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[ 1036383-27-3 ]
Yield | Reaction Conditions | Operation in experiment |
61.0% |
|
Example 15: Synthesis of 2-chloro-5-fluoro-4-hydroxy-benzaldehyde 111.[0184] 2-Chloro-5-fiuoro-4-hydroxy-benzaldehyde 111 was synthesized in one step from 2-chloro- 4,5-difluoro-bcnzaldchydc 110 as shown in Scheme 37.Step 1 - Preparation of2-chloro-5-fluoro-4-hydroxy-benzaldehyde (111)[0185] To <strong>[165047-23-4]2-chloro-4,5-difluoro-benzaldehyde</strong> (110, 0.40 g, 2.30 mmol, prepared as described in Example 14) in N,N-dimethylformamide (10 0 mL) were added 2-(2-methoxyethoxy)-ethanol, (0 327 g, 2 72 mmol) and cesium carbonate (0 886 g, 2 72 mmol) The reaction was stirred at 90 0C overnight The reaction was poured into water, acidified to pH around 5, and extracted with ethyl acetate The organic layer was dried over anhydrous sodium sulfate and filtered The filtrate was concentrated and purified by silica gel column chromatography elutmg with 30% ethyl acetate in <n="79"/>hexane to give a white solid (111. 0 24 g, 61 0%) MS (ESI) [M-H"] = 173 1 |