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[ CAS No. 1044870-39-4 ] {[proInfo.proName]}

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Chemical Structure| 1044870-39-4
Chemical Structure| 1044870-39-4
Structure of 1044870-39-4 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1044870-39-4 ]

CAS No. :1044870-39-4 MDL No. :MFCD18633270
Formula : C20H22N2O5 Boiling Point : -
Linear Structure Formula :- InChI Key :NETXMUIMUZJUTB-UHFFFAOYSA-N
M.W : 370.40 Pubchem ID :135564749
Synonyms :
RVX-208;RVX000222

Calculated chemistry of [ 1044870-39-4 ]

Physicochemical Properties

Num. heavy atoms : 27
Num. arom. heavy atoms : 16
Fraction Csp3 : 0.3
Num. rotatable bonds : 6
Num. H-bond acceptors : 6.0
Num. H-bond donors : 2.0
Molar Refractivity : 103.18
TPSA : 93.67 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : No
P-gp substrate : Yes
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : Yes
CYP2D6 inhibitor : Yes
CYP3A4 inhibitor : Yes
Log Kp (skin permeation) : -6.92 cm/s

Lipophilicity

Log Po/w (iLOGP) : 3.1
Log Po/w (XLOGP3) : 2.31
Log Po/w (WLOGP) : 2.6
Log Po/w (MLOGP) : 1.58
Log Po/w (SILICOS-IT) : 4.48
Consensus Log Po/w : 2.81

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -3.63
Solubility : 0.086 mg/ml ; 0.000232 mol/l
Class : Soluble
Log S (Ali) : -3.92
Solubility : 0.045 mg/ml ; 0.000122 mol/l
Class : Soluble
Log S (SILICOS-IT) : -6.7
Solubility : 0.0000732 mg/ml ; 0.000000198 mol/l
Class : Poorly soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 3.09

Safety of [ 1044870-39-4 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1044870-39-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1044870-39-4 ]
  • Downstream synthetic route of [ 1044870-39-4 ]

[ 1044870-39-4 ] Synthesis Path-Upstream   1~20

  • 1
  • [ 96-49-1 ]
  • [ 1044870-30-5 ]
  • [ 1044870-39-4 ]
YieldReaction ConditionsOperation in experiment
95% With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 12 h; Compound 10A (3.26 g, 10 mmol) was added to a 100 mL single-mouth bottle.Compound 11 is ethylene carbonate (0.88 g, 10 mmol),Add 30 mL of N,N-dimethylformamide to dissolve it.At the same time, potassium carbonate (1.38 g, 10 mmol) was added.Warm the system to 110 ° C,The reaction was refluxed for 12 hours.After the reaction is over,Add 20 mL of water to the reaction system.Extract three times with dichloromethane (3*20 mL),Combine the organic phase,Dry with anhydrous sodium sulfate,filter,Distilling under reduced pressure to obtain a mixture,Purified by column chromatography (the eluent is petroleum ether / ethyl acetate,Volume ratio 2:1),A yellow solid RVX-208 (3.51 g, yield 95percent) was obtained.
Reference: [1] Patent: CN108484510, 2018, A, . Location in patent: Paragraph 0041
  • 2
  • [ 1039948-89-4 ]
  • [ 63920-73-0 ]
  • [ 1044870-39-4 ]
YieldReaction ConditionsOperation in experiment
79.9% With toluene-4-sulfonic acid; sodium hydrogensulfite In ISOPROPYLAMIDE at 115℃; Intermediate 2 (58.74 kg), ?/,?/-dimethylacetamide (280 kg), and starting material 3 (56.00 kg) were combined and p-toluenesulfonic acid monohydrate (5.90 kg) and 1/3 of the required sodium bisulfite (24.1 kg) were added. The mixture was heated to 115 0C and stirred for 90-105 minutes before the second 1/3 of the required sodium bisulfite (24.1 kg) was added. The remaining sodium bisulfite (24.1 kg) was added after another 90-105 minutes. The reaction mixture was stirred at 115 0C until the reaction was complete as determined by HPLC (approximately 1 hour, less than 4percent of intermediate 2 remaining). The reaction mixture was cooled to 25 0C and added to water (1770 kg). The mixture was stirred at 20 0C for 6 hours to complete the crystallization. The crude material was isolated by filtration, washed with water (234 kg) and dried under vacuum to constant weight. The crude material was dissolved in ?/,?/-dimethylacetamide (252 kg) at 80 0C until all material had dissolved. The solution was cooled to 60 0C and heptane (918 kg) was slowly added over a period of 1 hour, maintaining a temperature above 35 0C.The solution was cooled to 35 0C and stirred at 35 0C for a minimum of 1 hour. The solid was isolated by filtration, washed with heptane (250 kg) and dried to constantweight under vacuum. Yield: 92.5percent; purity: 98.6percent. The dry solid (83.1 kg) was added to a 1 :1 mixture of ethanol and water (1V/1V; 1670 kg), and the mixture was heated to approximately 840C (reflux) until all material was in solution. The solution was cooled to 70 0C and polish-filtered, and then cooled to 30 0C over 2 hours. The solution was cooled to 0 0C. The mixture was stirred at 0 0C for at least 1 hour, before the material was isolated by filtration, washed with ethanol/water (1V/1V; 33 kg) and dried under vacuum to constant weight. The material was passed through a 60-mesh screen to afford 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7- dimethoxyquinazolin-4(3H)-one (4). Yield: 66.4 kg; 79.9percent.
62.7% With toluene-4-sulfonic acid; sodium hydrogensulfite In 1-methyl-pyrrolidin-2-one at 130℃; for 3 h; Inert atmosphere The intermediate H30-3 (15.2 g, 77.5 mol), H30-5 (15.06 g, 77.5 mmol), NAHSO3 (8.9 g, 85.3 mmol), P-TSA(1.34 g, 7.75 mmol), and NMP (140 mL) were added into a flask in the presence of nitrogen gas. The mixture was stirredfor 3 h at 130 °C. After the completion of the reaction detected by TLC, the mixture was extracted by adding water (450mL) and DCM (500 mL). The separated aqueous layer was extracted with DCM (4 3 400 mL). The resulting organiclayers were combined, washed with water (3 3 400 mL), dried by adding sodium sulfate, and filtered. The resultingfiltrate was distilled under reduced pressure. The resulting crude product was purified by silica gel column chromatography(eluent: dichloromethane: methanol = 80: 1) to give the intermediate H130: 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazoline-4(3H)-one (18 g, yield 62.7percent).
52% With toluene-4-sulfonic acid; sodium hydrogensulfite In N,N-dimethyl acetamide at 150℃; for 14 h; A solution of 2-amino-4,6-dimethoxybenzamide (0.60 g, 3.06 mmol) and 4-[2-(tert-butyidimethylsilanoxy)ethoxy]-3,5-dimethylbenzaldehyde (0.856 g, 2.78 mmol) in N,N-dimethyl formamide (20 mL) was stirred at 70° C. for 1 h. Iodine (0.846 g, 3.33 mmol) and potassium carbonate (0.384 g, 2.78 mmol) were added and the reaction mixture was stirred at 70° C. for 16 h. The reaction mixture was poured into ice, and extracted with ethyl acetate. The organic layer was washed with water, brine, and dried over anhydrous Na2SO4. Removal of the solvent gave the crude product which was purified by column chromatography to give 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (444 mg, 39percent) as a white solid. Selected data: 229-231° C.Alternatively, 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one can be synthesized by the following method. In a 2 L dry round-bottom flask with a reflux condenser and magnetic stirrer was placed 3,5-dimethyl-4-hydroxy benzaidehyde (26.9 g, 0.179 mol) in ethanol (350 mL). 2-chloroethanol (87.6 g, 1.074 mol) and K2CO3 (99 g, 0.716 mol) were added and the reaction mixture was heated to reflux for 24 h. The reaction mixture was cooled to room temperature and filtered. The solvent was removed under reduced pressure. The crude product was diluted with ethyl acetate and the organic layer was washed with water, brine, and dried over Na2SO4. Upon removal of solvent it gave 45 g of crude product. The crude product was purified by column chromatography (silica gel 230-400 mesh; 50percent ethyl acetate in hexane as eluent) to give 33.3 g (95percent) of product. To a solution of 2-amino-4,6-dimethoxy-benzamide (33.45 g, 0.170 mol) and 4-(2-hydroxy ethoxy)-3,5-dimethyl benzaldehyde (33.3 g, 0.170 mol) in N,N-dimethyl acetamide (300 mL), NaHSO3 (33.3 g, 0.187 mol) and p-TSA (3.2 g, 17.1 mmol) were added and the reaction mixture was heated at 150° C. for 14 h. The reaction was cooled to room temperature. The solvent was removed under reduced pressure. The residue was diluted with water and stirred for 30 min at room temperature. The solids separated were filtered and dried to give crude product. The crude product was purified by column chromatography (silica gel 230-400 mesh; 5percent methanol in CH2Cl2 as eluent) to give 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (33 g, 52percent).
52% With toluene-4-sulfonic acid; sodium hydrogensulfite In N,N-dimethyl acetamide at 150℃; for 14 h; To a solution of 2-amino-4,6-dimethoxy-benzamide (33.45 g, 0.170 mol) and 4-(2-hydroxy ethoxy)-3,5-dimethyl benzaldehyde (33.3 g, 0.170 mol) in N,N-dimethyl acetamide (300 mL), NaHSO3 (33.3 g, 0.187 mol) and p-TSA (3.2 g, 17.1 mmol) were added and the reaction mixture was heated at 150° C. for 14 h.
The reaction was cooled to room temperature.
The solvent was removed under reduced pressure.
The residue was diluted with water and stirred for 30 min at room temperature.
The solids separated were filtered and dried to give crude product.
The crude product was purified by column chromatography (silica gel 230-400 mesh; 5percent methanol in CH2Cl2 as eluent) to give 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (33 g, 52percent).
52% With toluene-4-sulfonic acid; sodium hydrogensulfite In N,N-dimethyl acetamide at 150℃; for 14 h; At 70deg.] C 2-Amino-4,6-dimethoxy-benzamide(0.60g, 3.06mmol) and 4- [2- (tert-butyldimethylsilyloxy)ethoxy]-3,5-dimethyl-benzaldehyde(0.856g,2.78mmol)in N, N- dimethylformamide(20 mL) was stirred for 1hour. Was added iodine (0.846g, 3.33mmol)and potassium carbonate (0.384g, 2.78mmol), thereaction mixture was at 70 stirred for 16 hours. The reactionmixture was poured onto ice, extracted with ethyl acetate. With water, theorganic layer was washed with brine, dried over anhydrous Na 2SO 4dry. The solvent was removed to give acrude product, which was purified by column chromatography to give a white solid of 2- (4- (2-hydroxyethoxy) -3,5-dimethylphenyl) -5,7-methoxy-quinazolin -4 (3H) - one (444mg, 39percent). Selected data: 229-231 . Alternatively, 2- (4-(2-hydroxyethoxy)-3,5-dimethyl-phenyl)-5,7-dimethoxy-quinazolin -4 (3H) - onecan be synthesized by the following method. In ethanol (350 mL of) of 3,5-dimethyl-4-hydroxy-benzaldehyde(26.9g, 0.179mol) disposed dried 2L round bottomed flask with refluxcondenser and magnetic stirrer. 2-chloro-ethanol(87.6g, 1.074mol) and K 2CO 3(99g, 0.716mol),the reaction mixture was heated at reflux for 24 hours. The reaction mixture was cooled toroom temperature and filtered. The solvent was removed under reduced pressure.The crude product was diluted with ethyl acetate, and the organic layer waswashed with water, brine, Na 2SO 4dry. 45g crude product obtained after removalof the solvent. The crude product was purified by column chromatography (silicagel 230-400 mesh; with 50percent hexanes in ethyl acetate as eluent) to afford 33.3g (95percent) of product. 2-amino-4,6-dimethoxy - benzamide (33.45g, 0.170mol)and 4- (2-hydroxyethoxy) -3,5-dimethyl benzaldehyde(33.3g, 0.170 mol) was added NaHSO3(33.3g,0.187mol) in N,N- dimethylacetamide (300mL) solution of and p-TSA(3.2g, 17.1mmol), at 150 reaction mixturewas heated for 14 hours.The reaction was cooled to room temperature. The solvent was removed underreduced pressure. The residue was diluted with water, followed by stirring at room temperature for30 minutes. The solid was isolated by filtration and dried to give the crudeproduct. The crude product was purified by column chromatography (silica gel230-400 mesh; used in CH 2Cl 25percent methanol as eluent) to afford 2- (4- (2-hydroxyethoxy) -3,5-dimethyl-phenyl)-5,7-dimethoxy-quinazoline -4 (3H) - one (33g, 52percent).
52% With toluene-4-sulfonic acid; sodium hydrogensulfite In ISOPROPYLAMIDE at 150℃; for 14 h; A solution of 2-amino-4,6-dimethoxyben2amide (0.60 g, 3.06 mmol) and 4-t2-(tert-butyldimethylsflanoxy)ethoxy]-3,5-dfmethylbenzaldehyde (0.856 g, 2.78 mmol) in λ/,/V-dimethyl formamide (20 mL) was stirred at 70°C for 1 h. Iodine (0.846 g, 3.33 mmol) and potassium carbonate (0.384 g, 2.78 mmol) were added and the reaction mixture was stirred at 70°C for 16 h, The reaction mixture was poured into ice, and extracted with ethyl acetate. The organic layer was washed with water, brine, and dried over anhydrous Na2SO4. Removal of the solvent gave the crude product which was purified by column chromatography to give 2-(4-{2- hydroxyethoxy)-3,5-dimethylphenyl)-5.7-dimethoxyquinazolin-4(3H)-one (444 mg, 39percent) as a white solid. Selected data: 229-231°C.[0117] Alternatively, 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7- dimethoxyquinazolin-4(3H)-one can be synthesized by the following method. In a 2 L dry round-bottom flask with a reflux condenser and magnetic stirrer was <n="65"/>placed 3, 5-dimethyl-4-hydroxy benzaldehyde (26.9 g, 0.179 mol) in ethanol (350 mL). 2-chloroethanol (87.6 g, 1.074 mol) and K2CO3 (99 g, 0.716 mol) were added and the reaction mixture was heated to reflux for 24 h. The reaction mixture was cooled to room temperature and filtered. The solvent was removed under reduced pressure. The crude product was diluted with ethyl acetate and the organic layer was washed with water, brine, and dried over Na2SO4. Upon removal of solvent it gave 45 g of crude product. The crude product was purified by column chromatography (silica gel 230-400 mesh; 50percent ethyl acetate in hexane as eluent) to give 33.3 g (95percent) of product, To a solution of 2-amino-4, 6- dimethoxy-benzamide (33.45 g, 0.170 mol) and 4-(2-hydroxy ethoxy)-3, 5- dimethyl benzaldehyde (33.3 g, 0.170 mol) in N,N-dimethyl acetamide (300 mL), NaHSOs (33.3 g, 0.187 mol) and p-TSA (3.2 g, 17.1 mmol) were added and the reaction mixture was heated at 150°C for 14 h. The reaction was cooled to room temperature. The solvent was removed under reduced pressure. The residue was diluted with water and stirred for 30 min at room temperature. The solids separated were filtered and dried to give crude product. The crude product was purified by column chromatography (silica gel 230-400 mesh; 5 percent methanol in CHzCI2 as eluent) to give 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7- dimethoxyquinazolin-4(3H)-one (33 g, 52percent).

Reference: [1] Patent: WO2009/158404, 2009, A1, . Location in patent: Page/Page column 16-17
[2] Patent: EP3348548, 2018, A1, . Location in patent: Paragraph 0060
[3] Patent: US2008/188467, 2008, A1, . Location in patent: Page/Page column 33
[4] Patent: US2013/281397, 2013, A1, . Location in patent: Paragraph 0477
[5] Patent: CN103319408, 2016, B, . Location in patent: Paragraph 0406-0410
[6] Patent: WO2008/92231, 2008, A1, . Location in patent: Page/Page column 63-64
  • 3
  • [ 1044872-73-2 ]
  • [ 62827-46-7 ]
  • [ 1044870-39-4 ]
YieldReaction ConditionsOperation in experiment
48% With ammonium hydroxide; L-valine; caesium carbonate; copper(I) bromide In dimethyl sulfoxide at 100℃; for 24 h; Sealed tube Take 2-bromo-4,6-dimethoxybenzamide (C-4) (388.5 mg, 1.50 mmol),Cuprous bromide (21.5 mg, 0.15 mmol), cesium carbonate (977.5 mg, 3.00 mmol),L-valine (34.5mg, 0.30mmol) in a thick-walled pressure tube,Add 5 ml of DMSO, intermediate B-3 (930 mg, 3.00 mmol), 1.90 ml of 26percent aqueous ammonia,Seal the pressure tube. The mixture was stirred at 100 ° C for 12 h, and then open for 12 h. Quenched with 6ml saturated ammonium chloride solution,Add 50 ml of ethyl acetate and 50 ml of distilled water.The mixture was separated and the aqueous layer was extracted with ethyl acetate (50ml×3).The organic layer was washed with distilled water (30 ml × 2) and saturated brine (30 ml).Dry over anhydrous sodium sulfate. Column chromatography, eluting with dichloromethane/methanol (v/v, 40:1) afforded 267 mg of Apabetalone.The yield was 48percent.
Reference: [1] Patent: CN108218798, 2018, A, . Location in patent: Paragraph 0061; 0062
  • 4
  • [ 1039948-89-4 ]
  • [ 1545025-44-2 ]
  • [ 1044870-39-4 ]
YieldReaction ConditionsOperation in experiment
81.5% With sodium hydroxide In tetrahydrofuran for 3.5 h; 2-Amino-4,6-dimethoxybenzonitrile 8.9 g (0.05 mol) and 4-(2-hydroxyethoxy)-3,5-dimethylbenzaldehyde 14.6 g were sequentially added to the reaction flask. (0.075mol),50ml of tetrahydrofuran, 0.05g of sodium hydroxide, stirred and refluxed for 3.5h,After the reaction is completed, ethyl acetate and water are successively added, and the organic phase is separated and washed with water.Drying, recovering ethyl acetate under reduced pressure, and the residue was crystallized from ethanol.15.1 g of 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one,The yield is 81.5percent.The purity is 99.7percent (area normalization method).
Reference: [1] Patent: CN108997226, 2018, A, . Location in patent: Paragraph 0036; 0045; 0054; 0055; 0062; 0063
  • 5
  • [ 1044872-73-2 ]
  • [ 63920-73-0 ]
  • [ 1044870-39-4 ]
YieldReaction ConditionsOperation in experiment
39% With iodine; potassium carbonate In N,N-dimethyl-formamide at 70℃; for 17 h; A solution of 2-amino-4,6-dimethoxybenzamide (0.60 g, 3.06 mmol) and 4-[2-(tert-butyidimethylsilanoxy)ethoxy]-3,5-dimethylbenzaldehyde (0.856 g, 2.78 mmol) in N,N-dimethyl formamide (20 mL) was stirred at 70° C. for 1 h. Iodine (0.846 g, 3.33 mmol) and potassium carbonate (0.384 g, 2.78 mmol) were added and the reaction mixture was stirred at 70° C. for 16 h. The reaction mixture was poured into ice, and extracted with ethyl acetate. The organic layer was washed with water, brine, and dried over anhydrous Na2SO4. Removal of the solvent gave the crude product which was purified by column chromatography to give 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (444 mg, 39percent) as a white solid. Selected data: 229-231° C.Alternatively, 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one can be synthesized by the following method. In a 2 L dry round-bottom flask with a reflux condenser and magnetic stirrer was placed 3,5-dimethyl-4-hydroxy benzaidehyde (26.9 g, 0.179 mol) in ethanol (350 mL). 2-chloroethanol (87.6 g, 1.074 mol) and K2CO3 (99 g, 0.716 mol) were added and the reaction mixture was heated to reflux for 24 h. The reaction mixture was cooled to room temperature and filtered. The solvent was removed under reduced pressure. The crude product was diluted with ethyl acetate and the organic layer was washed with water, brine, and dried over Na2SO4. Upon removal of solvent it gave 45 g of crude product. The crude product was purified by column chromatography (silica gel 230-400 mesh; 50percent ethyl acetate in hexane as eluent) to give 33.3 g (95percent) of product. To a solution of 2-amino-4,6-dimethoxy-benzamide (33.45 g, 0.170 mol) and 4-(2-hydroxy ethoxy)-3,5-dimethyl benzaldehyde (33.3 g, 0.170 mol) in N,N-dimethyl acetamide (300 mL), NaHSO3 (33.3 g, 0.187 mol) and p-TSA (3.2 g, 17.1 mmol) were added and the reaction mixture was heated at 150° C. for 14 h. The reaction was cooled to room temperature. The solvent was removed under reduced pressure. The residue was diluted with water and stirred for 30 min at room temperature. The solids separated were filtered and dried to give crude product. The crude product was purified by column chromatography (silica gel 230-400 mesh; 5percent methanol in CH2Cl2 as eluent) to give 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (33 g, 52percent).
39%
Stage #1: at 70℃; for 1 h;
Stage #2: With iodine; potassium carbonate In N,N-dimethyl-formamide at 70℃; for 16 h;
2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one [0476] A solution of 2-amino-4,6-dimethoxybenzamide (0.60 g, 3.06 mmol) and 4-[2-(tert-butyldimethylsilanoxy)ethoxy]-3,5-dimethylbenzaldehyde (0.856 g, 2.78 mmol) in N,N-dimethyl formamide (20 mL) was stirred at 70° C. for 1 h. Iodine (0.846 g, 3.33 mmol) and potassium carbonate (0.384 g, 2.78 mmol) were added and the reaction mixture was stirred at 70° C. for 16 h. The reaction mixture was poured into ice, and extracted with ethyl acetate. The organic layer was washed with water, brine, and dried over anhydrous Na2SO4. Removal of the solvent gave the crude product which was purified by column chromatography to give 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (444 mg, 39percent) as a white solid. Selected data: 229-231° C.
39%
Stage #1: at 70℃; for 1 h;
Stage #2: at 70℃; for 16 h;
At 70deg.] C 2-Amino-4,6-dimethoxy-benzamide(0.60g, 3.06mmol) and 4- [2- (tert-butyldimethylsilyloxy)ethoxy]-3,5-dimethyl-benzaldehyde(0.856g,2.78mmol)in N, N- dimethylformamide(20 mL) was stirred for 1hour. Was added iodine (0.846g, 3.33mmol)and potassium carbonate (0.384g, 2.78mmol), thereaction mixture was at 70 stirred for 16 hours. The reactionmixture was poured onto ice, extracted with ethyl acetate. With water, theorganic layer was washed with brine, dried over anhydrous Na 2SO 4dry. The solvent was removed to give acrude product, which was purified by column chromatography to give a white solid of 2- (4- (2-hydroxyethoxy) -3,5-dimethylphenyl) -5,7-methoxy-quinazolin -4 (3H) - one (444mg, 39percent). Selected data: 229-231 . Alternatively, 2- (4-(2-hydroxyethoxy)-3,5-dimethyl-phenyl)-5,7-dimethoxy-quinazolin -4 (3H) - onecan be synthesized by the following method. In ethanol (350 mL of) of 3,5-dimethyl-4-hydroxy-benzaldehyde(26.9g, 0.179mol) disposed dried 2L round bottomed flask with refluxcondenser and magnetic stirrer. 2-chloro-ethanol(87.6g, 1.074mol) and K 2CO 3(99g, 0.716mol),the reaction mixture was heated at reflux for 24 hours. The reaction mixture was cooled toroom temperature and filtered. The solvent was removed under reduced pressure.The crude product was diluted with ethyl acetate, and the organic layer waswashed with water, brine, Na 2SO 4dry. 45g crude product obtained after removalof the solvent. The crude product was purified by column chromatography (silicagel 230-400 mesh; with 50percent hexanes in ethyl acetate as eluent) to afford 33.3g (95percent) of product. 2-amino-4,6-dimethoxy - benzamide (33.45g, 0.170mol)and 4- (2-hydroxyethoxy) -3,5-dimethyl benzaldehyde(33.3g, 0.170 mol) was added NaHSO3(33.3g,0.187mol) in N,N- dimethylacetamide (300mL) solution of and p-TSA(3.2g, 17.1mmol), at 150 reaction mixturewas heated for 14 hours.The reaction was cooled to room temperature. The solvent was removed underreduced pressure. The residue was diluted with water, followed by stirring at room temperature for30 minutes. The solid was isolated by filtration and dried to give the crudeproduct. The crude product was purified by column chromatography (silica gel230-400 mesh; used in CH 2Cl 25percent methanol as eluent) to afford 2- (4- (2-hydroxyethoxy) -3,5-dimethyl-phenyl)-5,7-dimethoxy-quinazoline -4 (3H) - one (33g, 52percent).
Reference: [1] Patent: US2008/188467, 2008, A1, . Location in patent: Page/Page column 33
[2] Patent: US2013/281397, 2013, A1, . Location in patent: Paragraph 0476
[3] Patent: CN103319408, 2016, B, . Location in patent: Paragraph 0406-0410
  • 6
  • [ 2233-18-3 ]
  • [ 1044870-39-4 ]
Reference: [1] Patent: US2013/281397, 2013, A1,
[2] Patent: CN103319408, 2016, B,
[3] Patent: CN108218798, 2018, A,
[4] Patent: EP3348548, 2018, A1,
[5] Patent: WO2008/92231, 2008, A1,
  • 7
  • [ 21544-81-0 ]
  • [ 1044870-39-4 ]
Reference: [1] Patent: US2013/281397, 2013, A1,
[2] Patent: US2013/281397, 2013, A1,
[3] Patent: CN103319408, 2016, B,
[4] Patent: CN103319408, 2016, B,
[5] Patent: WO2008/92231, 2008, A1,
[6] Patent: WO2008/92231, 2008, A1,
  • 8
  • [ 10272-07-8 ]
  • [ 1044870-39-4 ]
Reference: [1] Patent: US2013/281397, 2013, A1,
[2] Patent: US2013/281397, 2013, A1,
[3] Patent: CN108484510, 2018, A,
[4] Patent: WO2008/92231, 2008, A1,
[5] Patent: WO2008/92231, 2008, A1,
  • 9
  • [ 21577-57-1 ]
  • [ 1044870-39-4 ]
Reference: [1] Patent: CN103319408, 2016, B,
[2] Patent: CN103319408, 2016, B,
[3] Patent: EP3348548, 2018, A1,
[4] Patent: WO2008/92231, 2008, A1,
[5] Patent: WO2008/92231, 2008, A1,
  • 10
  • [ 40891-33-6 ]
  • [ 1044870-39-4 ]
Reference: [1] Patent: US2013/281397, 2013, A1,
[2] Patent: US2013/281397, 2013, A1,
[3] Patent: WO2008/92231, 2008, A1,
[4] Patent: WO2008/92231, 2008, A1,
  • 11
  • [ 63920-73-0 ]
  • [ 1044870-39-4 ]
Reference: [1] Patent: CN108484510, 2018, A,
[2] Patent: WO2008/92231, 2008, A1,
  • 12
  • [ 20469-65-2 ]
  • [ 1044870-39-4 ]
Reference: [1] Patent: CN108218798, 2018, A,
  • 13
  • [ 81574-69-8 ]
  • [ 1044870-39-4 ]
Reference: [1] Patent: CN108218798, 2018, A,
  • 14
  • [ 62827-49-0 ]
  • [ 1044870-39-4 ]
Reference: [1] Patent: CN108218798, 2018, A,
  • 15
  • [ 99-10-5 ]
  • [ 1044870-39-4 ]
Reference: [1] Patent: CN108484510, 2018, A,
  • 16
  • [ 1132-21-4 ]
  • [ 1044870-39-4 ]
Reference: [1] Patent: CN108484510, 2018, A,
  • 17
  • [ 85657-94-9 ]
  • [ 1044870-39-4 ]
Reference: [1] Patent: CN108484510, 2018, A,
  • 18
  • [ 1599437-13-4 ]
  • [ 1044870-39-4 ]
Reference: [1] Patent: CN108484510, 2018, A,
  • 19
  • [ 1545025-44-2 ]
  • [ 1044870-39-4 ]
Reference: [1] Patent: CN108484510, 2018, A,
  • 20
  • [ 2735-04-8 ]
  • [ 1044870-39-4 ]
Reference: [1] Patent: CN108997226, 2018, A,
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