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[ CAS No. 104831-79-0 ] {[proInfo.proName]}

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Chemical Structure| 104831-79-0
Chemical Structure| 104831-79-0
Structure of 104831-79-0 * Storage: {[proInfo.prStorage]}
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Product Details of [ 104831-79-0 ]

CAS No. :104831-79-0 MDL No. :
Formula : C17H15NO2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 265.31 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 104831-79-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 104831-79-0 ]
  • Downstream synthetic route of [ 104831-79-0 ]

[ 104831-79-0 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 104831-79-0 ]
  • [ 1066-54-2 ]
  • [ 2975-46-4 ]
YieldReaction ConditionsOperation in experiment
82%
Stage #1: With n-butyllithium In hexane
Stage #2: at 0℃; for 8 h;
General procedure: To the ice-cold solution of aldehyde in THF was added, the solution of alkylmagnesium halide or alkyllithium in THF (1.3 eq., at 0 °C). The reaction was stirred at 0 °C for 1 h, diluted with saturated aq. NH4Cl (10 mL) and ethyl acetate (10 mL). Aqueous layer was extracted with ethyl acetate (2×10 mL). The combined organic layers were washed with brine (10 mL), and dried over Na2SO4. Evaporation of the solvent and purification of the crude mixture by column chromatography (9:1, hexane: EtOAc) gave the corresponding bisindolylmethane derivatives (BIM) up to 92percent yields along with the by-product aldehyde.
Reference: [1] Tetrahedron, 2016, vol. 72, # 49, p. 8106 - 8116
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