Alternatived Products of [ 105314-71-4 ]
Product Details of [ 105314-71-4 ]
CAS No. : | 105314-71-4 |
MDL No. : | |
Formula : |
C23H26ClN5O5
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
487.94
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 105314-71-4 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 105314-71-4 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 105314-71-4 ]
- 1
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[ 74191-85-8 ]
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[ 105314-71-4 ]
Yield | Reaction Conditions | Operation in experiment |
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With hydrogenchloride In water; acetone at 10 - 25℃; |
5
Example 5 Doxazosin base (0.110 mol; 49.61 g) was charged in acetone (750 ml) and stirred at 25° C. to obtain slurry. On cooling the slurry to 10-15° C., hydrochloric acid solution was added till the pH was 2-3. The contents were stirred for 10-15 min at 10-15° C. and then stirring continued at 25° C. for 2 hr. The solid obtained was filtered, washed with acetone and dried at 50-55° C. to obtain solid product. The solid was purified by refluxing with methanol (600 ml) for 1 hr. The slurry was cooled to room temperature, filtered, washed with methanol and then dried at 60° C. under reduced pressure to obtain 51 g of pure doxazosin hydrochloride (HPLC purity -99.77%). |