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[ CAS No. 1073159-68-8 ] {[proInfo.proName]}

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Chemical Structure| 1073159-68-8
Chemical Structure| 1073159-68-8
Structure of 1073159-68-8 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1073159-68-8 ]

CAS No. :1073159-68-8 MDL No. :MFCD28405940
Formula : C7H8N4O2S Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 212.23 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 1073159-68-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1073159-68-8 ]

[ 1073159-68-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1184-85-6 ]
  • [ 55557-52-3 ]
  • [ 1073159-68-8 ]
YieldReaction ConditionsOperation in experiment
73.43% With caesium carbonate; In acetonitrile; at 25 - 80℃; for 20h; Step 1. Preparation of N-(3-cyano-pyrazin-2-yl)-N-methyl-methane sulfonamide (B2-1): A solution of chloropyrazine-2-carbonitrile (4.2 g, 30.21 mmol) in acetonitrile (200 mL) at 25 C. was treated sequentially with Cs2CO3 (13.7831 g, 42.293 mmol) and N-methyl-methane sulfonamide (3.957 g, 36.25 mmol). The mixture was then heated to 80 C. After about 20 hours the mixture was cooled to 25 and filtered. The solids were washed with EtOAc (3*25 mL) and the combined filtrates were concentrated. The resultant residue was treated with water (50 mL) and extracted with EtOAc (3*75 mL). The combined organic layers were washed with water (50 mL), brine, dried over anhydrous sodium sulfate and concentrated. The resultant residue was purified by column chromatography (100-200 mesh silica gel; 40% EtOAc in petroleum ether as eluding solvent) to provide B2-1 as a pale brown liquid. Yield: 4.7 g, 73.43%). 1H NMR (CDCl3) delta: 8.92 (d, 2H), 3.4 (s, 3H) and 3.25 (s, 3H). Mass: (M+1) 213 calculated for C7H8N4O2S. (Note: The product contained unreacted N-methanesulfonamide as an impurity.
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