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[ CAS No. 1094071-11-0 ] {[proInfo.proName]}

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Chemical Structure| 1094071-11-0
Chemical Structure| 1094071-11-0
Structure of 1094071-11-0 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1094071-11-0 ]

CAS No. :1094071-11-0 MDL No. :MFCD12177582
Formula : C10H13NO4S Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 243.28 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 1094071-11-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1094071-11-0 ]

[ 1094071-11-0 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 4282-31-9 ]
  • [ 75-65-0 ]
  • [ 1094071-11-0 ]
YieldReaction ConditionsOperation in experiment
81% With diphenylphosphoranyl azide; triethylamine; for 24h;Reflux; Add 5.16 g (30 mmol) of thiophene-2,5-dicarboxylic acid to the reaction flask.8.25 g (30 mmol) of diphenylphosphoryl azide, 6.06 g (60 mmol) of triethylamine and 140 mL of tert-butanol,The reaction was heated to reflux for 24 hours, the reaction mixture was allowed to cool to room temperature, and the excess tert-butanol was removed by rotary evaporation.Crude 5-(N-tert-butoxycarbonyl)-aminothiophene-2-carboxylic acid (Compound 2) was obtained,A suitable amount of ethyl acetate was added thereto to dissolve, and successively washed with 5% sodium bicarbonate (10 mL×3), 5% citric acid (10 mL×3), saturated sodium chloride solution (10 mL×3), and dried over anhydrous sodium sulfate. . Filter, wash, remove solvent,Purification by column chromatography (ethyl acetate:petroleum ether=1:1, v/v) gave 5.90 g of a white solid, yield 81%
With diphenyl phosphoryl azide; triethylamine; for 5h;Heating / reflux; EXAMPLE 52A solution of thiophene-2,5-dicarboxylic acid (2.73 g, 15.84 mmol), diphenylphosphoryl azide (3.41 mL g, 15.84 mmol) and triethylamine (4.4 mL, 31.68 mmol) in tert-butanol (80 mL) was heated at refluxing 5h. The reaction mixture was cooled to room temperature and then concentrated to afford the crude title compound. HPLC-MS tR =1.52 Min (UV 254nm)- Mass calculated for M+ 243.0, observed LC/MS m/z 244.1 (M+H).
With diphenylphosphoranyl azide; triethylamine; at 82℃; for 5h; a) 5-Carbokappay-2-t°/t-butoxycarbonylaminothiophene; 1.45 mL (10.4 mmol) of TEA, and 1.11 ml_ (5.2 mmol) of diphenylphosphory. azide were added to a solution of thiophene-2,5-dicarboxylic acid (895 mg, 5.2 mmol) in terf-butanoi (30 mL). The reaction mixture was stirred at 82 0C for 5 h. The solvent was then evaporated to dryness. The desired compound was obtained and used in next step without further purification.
  • 2
  • [ 14597-58-1 ]
  • [ 1094071-11-0 ]
  • 3
  • [ 1094071-11-0 ]
  • [ 112889-02-8 ]
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