Alternatived Products of [ 1094346-39-0 ]
Product Details of [ 1094346-39-0 ]
CAS No. : | 1094346-39-0 |
MDL No. : | |
Formula : |
C14H10N7O
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
292.28
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 1094346-39-0 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 1094346-39-0 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1094346-39-0 ]
- 1
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[ 51605-32-4 ]
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[ 1094346-39-0 ]
- 2
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[ 35445-32-0 ]
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[ 1094346-39-0 ]
Yield | Reaction Conditions | Operation in experiment |
52% |
With hydrazine hydrate; In ethanol; for 32h;Reflux; |
ethyl 1 ,4-dimethyl-1 H-imidazole-5-carboxylate (185 mg, 1.10 mmol, 1 eq) dissolved in ethanol (25 ml.) was treated with hydrazine hydrate (5 ml.) at reflux for 16 h with stirring. Additional hydrazine hydrate (20 ml.) was added to the reaction mixture and heated at reflux for an additional 16 h with stirring. The reaction mixture was concentrated to dryness, chased with twice with ethanol and twice with toluene, and pumped dry to give a white solid. The crude product was triturated wit 5percent CH3OH/DCM and filtered. The filtrate was concentrated to dryness and was purified on a 40 g silica gel cartridge eluted with 0 to 20percent CH3OH/DCM to give the title compound (90 mg, 0.58 mmol, 52percent) as a white solid. 1 H NMR (400 MHz, DMSO-d6) delta ppm 9.12 (br. s., 1 H), 7.56 (s, 1 H), 4.45 (br. s., 2 H), 3.64 (s, 3 H), 2.21 (s, 3 H). |
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With hydrazine; In ethanol; water; at 100℃; |
To a solution of <strong>[35445-32-0]ethyl 1,4-dimethyl-1H-imidazole-5-carboxylate</strong> (2.6 g, 14 mmol) in EtOH (16 mL) at room temperature is added hydrazine in water (4 mL, 102.9 mmol) slowly over 2 min The mixture is then stirred at 100° C. overnight. The mixture is concentrated and lyophilized to give the title compound (2.3 g, 97percent) as a white solid, which can be used without further purification. LC/MS (m/z): 155 (M+H). |