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CAS No. : | 111953-15-2 | MDL No. : | MFCD17169929 |
Formula : | C11H14ClNO3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 243.69 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In ethanol; at 60℃; | General procedure: To a solution of <strong>[86129-63-7]2,4-dichloro-6-methylnicotinic acid ethyl ester</strong> (2.49 mmol) in 6 mL EtOH was added NaOEt (2.61 mmol). The reaction mixture was heated to 60C overnight in a closed vessel. At RT, the mixture was diluted with EtOAc and washed with aq. NH4CI solution. The organic layer was dried over MgS04 and concentrated in vacuo. Purification by (KP-SIL from Biotage) using Hept/EtOAc (1/1 ) gives the desired product as beige solid; LC-MS (C): tR = 0.83 min; [M+H]+: 244.13. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With AMINOHIPPURATE SODIUM; In ethanol; | A.2.17.1 Synthesis of 2-chloro-4-ethoxy-6-methylnicotinic acid ethyl ester To a solution of <strong>[86129-63-7]2,4-dichloro-6-methylnicotinic acid ethyl ester</strong> (2.49 mmol) in 6 mL EtOH was added NaOEt (2.61 mmol). The reaction mixture was heated to 60 C. overnight in a closed vessel. At RT, the mixture was diluted with EtOAc and washed with aq. NH4Cl solution. The organic layer was dried over MgSO4 and concentrated in vacuo. Purification by (KP-SIL from Biotage) using Hept/EtOAc (1/1) gives the desired product as beige solid; LC-MS (C): tR=0.83 min; [M+H]+: 244.13. |