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[ CAS No. 112146-11-9 ] {[proInfo.proName]}

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Chemical Structure| 112146-11-9
Chemical Structure| 112146-11-9
Structure of 112146-11-9 * Storage: {[proInfo.prStorage]}
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Product Details of [ 112146-11-9 ]

CAS No. :112146-11-9 MDL No. :MFCD02073523
Formula : C10H5F3N2S Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 242.22 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 112146-11-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 112146-11-9 ]

[ 112146-11-9 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 7357-70-2 ]
  • [ 105202-02-6 ]
  • [ 112146-11-9 ]
  • 2
  • [ 5355-68-0 ]
  • [ 112146-11-9 ]
  • 6-isopropyl-3-(5-(trifluoromethyl)benzo[d]thiazol-2-yl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
62% With morpholine; sulfur; In ethanol; at 80℃; for 16h; To a solution of 2-(5-(trifluoromethyl)benzo[djthiazol-2-yl)acetonitrile 1 (2 g, 8.264 mmol) in ethanol (20 mL) was added 1-isopropylpiperidin-4-one (1.16 g, 8.264 mmol), elemental sulphur (264 mg, 8.264 mmol) and morpholine (700 mg, 8.264 mmol) at room temperature. After the addition, the resulting mixture was heated to reflux at 80 C for 16 h. Progress of the reaction was monitored by TLC. After completion, the reaction mixture was evaporated in vacuum up to dryness. The crude compound was purified by column chromatography eluting with 0-40% ethyl acetate in n-hexane to afford the title compound 2 as off white solid (2 g, yield 62%).
  • 3
  • [ 604010-24-4 ]
  • [ 112146-11-9 ]
  • tert-butyl 2-acrylamido-5,7-dimethyl-3-(5-(trifluoromethyl)benzo[d]thiazol-2-yl)4,7-dihydrothieno[2,3-c]pyridine-6(5H)-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With morpholine; sulfur; at 85℃; for 3h; To a solution of 2-(5-(trifluoromethyl)benzo[djthiazol-2-yl)acetonitrile 1 (0.500 g, 2.05 mmol), elemental sulphur (0.065 g, 2.05 mmol) and morpholine (0.2 mL, 2.05 mmol) was added <strong>[604010-24-4]tert-butyl 2,6-dimethyl-4-oxopiperidine-1-carboxylate</strong> (0.467g, 2.05 mmol) at room temperature and the resulting reaction mixture was heated to reflux at 85 C for 3 h. Reaction was monitored by TLC. After the completion, reaction mixture was evaporated to dryness on rotavapour and the crude compound. This crude compound was purified by silica gel column chromatography eluting with 0-10% methanol in CH2C12 to afford title compound 4 as yellow solid 2 as brown solid (0.300 g, 30%).
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