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[ CAS No. 1135872-25-1 ] {[proInfo.proName]}

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Chemical Structure| 1135872-25-1
Chemical Structure| 1135872-25-1
Structure of 1135872-25-1 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1135872-25-1 ]

CAS No. :1135872-25-1 MDL No. :MFCD31654497
Formula : C16H16BrNO4 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 366.21 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 1135872-25-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1135872-25-1 ]

[ 1135872-25-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 321601-48-3 ]
  • [ 588-63-6 ]
  • [ 1135872-25-1 ]
YieldReaction ConditionsOperation in experiment
60% With sodium hydride In ISOPROPYLAMIDE at 90℃; for 3h; 67.a a) 6-Bromo-3-(3-phenoxy-propoxy)-pyridine-2-carboxylic acid methyl esterA mixture of -bromo-3-hydroxypicolinic acid methyl ester (lOOmg, 0.43 mmol), sodium hydride (60% dispersion in mineral oil) (17.3mg, 0.43 mmol), 3-phenoxypropyl bromide(68 μL, 0.43 mmol), in dimethyl acetamide (1.5 mL) was heated at 9O0C for 3 hours. The reaction was allowed to cool, poured onto water and then extracted with ethyl acetate (2 x3mL). The organic layer was dried (MgSO4) and concentrated in vacuo. The resulting residue was purified by silica chromatography eluting with 100% petroleum ether to 30% ethyl acetate/petroleum ether to obtain a white solid (95mg, 60%). 1H NMR (300 MHz,CDCl3) δ: 7.48 (IH, d), 7.24-7.21 (3H, m), 6.91-6.86 (3H, m), 4.19 (2H, t), 4.15 (2H, t),3.88 (3H, s), 2.30-2.22 (2H, m).
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