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[ CAS No. 1137279-00-5 ] {[proInfo.proName]}

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Chemical Structure| 1137279-00-5
Chemical Structure| 1137279-00-5
Structure of 1137279-00-5 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1137279-00-5 ]

CAS No. :1137279-00-5 MDL No. :N/A
Formula : C10H11ClN4OS2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 302.80 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 1137279-00-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1137279-00-5 ]

[ 1137279-00-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 110-91-8 ]
  • [ 87789-35-3 ]
  • [ 1137279-00-5 ]
  • [ 1137279-05-0 ]
YieldReaction ConditionsOperation in experiment
In methanol; at 20℃; for 0.5h; The crude brown solid was slurried in methanol and morpholine (6eq) was added. The solution was stirred at room temperature for 30 min, solvent was removed under vacuum and ethyl acetate was added. The organic was washed with saturated sodium bicarbonate solution. Both the precipitate and the organic layers contained product and were subjected to silica gel chromatography to yield 5-chloro-2-(methylthio)-7-morpholinothiazolo[4,5-d]pyrimidine 78 and 5-chloro-2,7-dimorpholinothiazolo[4,5-d]pyrimidine 79.
  • 2
  • [ 1137279-00-5 ]
  • [ 173979-01-6 ]
  • [ 1137279-01-6 ]
YieldReaction ConditionsOperation in experiment
With copper(l) iodide; cesium fluoride;tetrakis(triphenylphosphine) palladium(0); In N,N-dimethyl-formamide; at 110℃; for 0.25h;Microwave irradiation; Example 63; 5-(7-Morpholino-2-(thiazol-4-yl)thiazolo[4,5-d]pyrimidin-5- yl)pyrimidin-2-amine 138[00376] 5-Chloro-2-(methylthio)-7-morpholinothiazolo[4,5-d]pyrimidine was combined with <strong>[173979-01-6]4-(tributylstannyl)thiazole</strong> (1.1 eq), cesium fluoride (2 eq), copper iodide (2 eq), tetrakis(triphenylphosphine)palladium (0.1 eq) in dimethylformamide and microwaved 110 C for 15 minutes. Methylene chloride was added the solution was filtered through silica washing with methanol. The organic layer was evaporated to dryness and the resulting residue was purified by silica gel chromatography to yield 5-chloro-7-morpholino-2-(thiazol-4- yl)thiazolo[4,5-d]pyrimidine as a pale yellow solid.
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