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[ CAS No. 1159817-43-2 ] {[proInfo.proName]}

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Chemical Structure| 1159817-43-2
Chemical Structure| 1159817-43-2
Structure of 1159817-43-2 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1159817-43-2 ]

CAS No. :1159817-43-2 MDL No. :
Formula : C9H12N2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 148.21 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 1159817-43-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1159817-43-2 ]

[ 1159817-43-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 372118-01-9 ]
  • [ 1159817-43-2 ]
  • [ 1446792-27-3 ]
YieldReaction ConditionsOperation in experiment
17.5% In acetonitrile; at 80℃; for 48h;Sealed tube; Step 1 Methyl 6-chloro-4-(6-cyclobutylpyridin-2-ylamino)pyridazine-3-carboxylate A heavy walled resealable tube was charged with <strong>[372118-01-9]methyl 4,6-dichloropyridazine-3-carboxylate</strong> (1.3 g, 6.28 mmol) and 6-cyclobutylpyridin-2-amine (931 mg, 6.28 mmol) in acetonitrile (6.00 mL). The tube was heated with stirring in an oil bath at 80 C. for 48 h. Solvent was evaporated under vacuum, the residue was dissolved in dichloromethane and then purified by flash chromatography (spherical silica 20-45 muM, 50 g, Versaflash Supelco) eluting with 0 to 10% over 20 min dichloromethane/acetone to give methyl 6-chloro-4-(6-cyclobutylpyridin-2-ylamino)pyridazine-3-carboxylate (350 mg, 17.5% yield) as a light yellow solid. 1H NMR (CHLOROFORM-d) delta: 10.62 (s, 1H), 9.49 (s, 1H), 7.59 (t, J=7.9 Hz, 1H), 6.85 (d, J=7.6 Hz, 1H), 6.73 (d, J=8.3 Hz, 1H), 4.10 (s, 3H), 3.67 (quin, J=8.6 Hz, 1H), 2.24-2.58 (m, 4H), 1.85-2.22 (m, 2H); LC-MS 319.0 [M+H]+.
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