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[ CAS No. 1183678-32-1 ]

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2D
Chemical Structure| 1183678-32-1
Chemical Structure| 1183678-32-1
Structure of 1183678-32-1 *Storage: {[proInfo.prStorage]}

Quality Control of [ 1183678-32-1 ]

Related Doc. of [ 1183678-32-1 ]

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Alternatived Products of [ 1183678-32-1 ]
Alternatived Products of [ 1183678-32-1 ]

Product Details of [ 1183678-32-1 ]

CAS No. :1183678-32-1MDL No. :MFCD12807208
Formula : C9H9F3N2O2 Boiling Point : -
Linear Structure Formula :-InChI Key :-
M.W :234.18Pubchem ID :-
Synonyms :

Computed Properties of [ 1183678-32-1 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 1183678-32-1 ]

Signal Word:Class:
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Application In Synthesis of [ 1183678-32-1 ]

  • Downstream synthetic route of [ 1183678-32-1 ]

[ 1183678-32-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 367-67-9 ]
  • [ 75-04-7 ]
  • [ 1183678-32-1 ]
YieldReaction ConditionsOperation in experiment
In ethanol; at 80℃; for 18h; A mixture of 2-bromo-5-nitrobenzotrifuoride (Lancaster Synthesis, GmbH; 5.4 g, 20 [MMOL)] and a solution of ethylamin in ethanol (50 mL of 2M, 100 [MMOL)] is heated at [80C] for 18 hours in a steel pressure vessel. The mixture is then cooled and the solvent is evaopated off under reduced pressure to yield the crude product which is purified by column chromatography (silica gel, eluent 20% ethyl acetate in hexane) to afford N-ethyl-4-nitro-6- (trifluoromethyl)- benzenamine as yellow oil. This product is dissolved in ethanol (180 mL) and hydrogenated at atmospheric pressure over Raney nickel (0.5 g) at [45C.] The calculated amount of hydrogen is taken up in 50 hours. The mixture is then filtered and the solvent is evaporated off under reduced pressure to yield the crude product which is purified by chromatography (silica gel ; eluent 50% ethyl acetate in hexane) and recrystallised from ether-hexane to give the title compound as a beige crystalline solid. 1 H-NMR (400 MHz, [DMSO-D6)] : [1. 11] (t, 3H), 3.05 (m, 2H), 4.18 (br t, 1 H), 4.66 (br. s, 2H), 6.58-6. 64 (m, 1 H) and 6.68-6. 75 (m, 2H).
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