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[ CAS No. 120077-69-2 ] {[proInfo.proName]}

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3d Animation Molecule Structure of 120077-69-2

Chemical Structure| 120077-69-2

Chemical Structure| 120077-69-2

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Quality Control of [ 120077-69-2 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 120077-69-2 ]

SDS Specification

Alternatived Products of [ 120077-69-2 ]

Product Details of [ 120077-69-2 ]

CAS No. :	120077-69-2	MDL No. :	MFCD08059110
Formula :	C₇H₄BrClO	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	LDYVDYZLCRUOTM-UHFFFAOYSA-N
M.W :	219.46	Pubchem ID :	14049806
Synonyms :

Calculated chemistry of [ 120077-69-2 ]

Physicochemical Properties

Num. heavy atoms :	10
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.0
Num. rotatable bonds :	1
Num. H-bond acceptors :	1.0
Num. H-bond donors :	0.0
Molar Refractivity :	44.54
TPSA :	17.07 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.59 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.81
Log Po/w (XLOGP3) :	2.88
Log Po/w (WLOGP) :	2.92
Log Po/w (MLOGP) :	2.79
Log Po/w (SILICOS-IT) :	3.3
Consensus Log Po/w :	2.74

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-3.39
Solubility :	0.0888 mg/ml ; 0.000405 mol/l
Class :	Soluble
Log S (Ali) :	-2.9
Solubility :	0.277 mg/ml ; 0.00126 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-3.82
Solubility :	0.0331 mg/ml ; 0.000151 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.23

Safety of [ 120077-69-2 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 120077-69-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 120077-69-2 ]
Downstream synthetic route of [ 120077-69-2 ]

[ 120077-69-2 ] Synthesis Path-Upstream 1~8

1
[ 120077-69-2 ]
[ 25118-59-6 ]

Reference： [1] Journal of the Chemical Society, 1927, p. 25

2
[ 1235711-34-8 ]
[ 120077-69-2 ]

Yield	Reaction Conditions	Operation in experiment
84%	Stage #1: With diisobutylaluminium hydride In tetrahydrofuran at -78℃; Inert atmosphere Stage #2: With water In tetrahydrofuran	PREPARATION C : 4-bromo-3-chlorobenzaldehyde; [Show Image] Under argon, at -78°C, a 10 mL one-necked round bottomed flask was charged with 4-bromo-3-chloro-N-methoxy-N-methyl-benzamide (preparation B) (1.80 g, 6.46 mmol) in dry tetrahydrofuran (32 mL). Then, a 1M solution of diisobutylaluminiumhydride (8.4 mL, 8.40 mmol) was then added dropwise. The reaction mixture was stirred at -78°C during 1 hour. The reaction mixture was quenched with water (50 mL) and the aqueous layer was extracted with ethyl acetate (3 x 50 mL). The organic layer was washed with a 1 N hydrochloric acid solution (30 mL), water (30 mL), brine (30 mL), dried over anhydrous magnesium sulfate and evaporated in vacuo. The product was dried under high vacuum yielding 4-bromo-3-chlorobenzaldehyde (1.18 g, 84percent) as a yellow solid. ¹H NMR (300 MHz, DMSO-d₆): δ 9.98 (s, 1H), 8.11 (d, 1H, J=1.9 Hz), 8.02 (AB system, 1H, J=8.2 Hz), 7.77 (dd, 1H, J=1.9 Hz, 8.2 Hz).

Reference： [1] Patent: EP2208725, 2010, A1, . Location in patent: Page/Page column 13

3
[ 57418-97-0 ]
[ 120077-69-2 ]

Reference： [1] Journal of Medicinal Chemistry, 2011, vol. 54, # 11, p. 3793 - 3816

4
[ 79-37-8 ]
[ 67-68-5 ]
[ 120077-69-2 ]

Reference： [1] Patent: US5502073, 1996, A,

5
[ 25118-59-6 ]
[ 120077-69-2 ]

Reference： [1] Journal of Medicinal Chemistry, 2012, vol. 55, # 23, p. 10572 - 10583
[2] Patent: WO2013/75083, 2013, A1,
[3] Patent: WO2014/8223, 2014, A2,
[4] Patent: US9206128, 2015, B2,
[5] Patent: WO2017/84630, 2017, A1,

6
[ 21803-75-8 ]
[ 120077-69-2 ]

Reference： [1] Journal of Medicinal Chemistry, 2011, vol. 54, # 11, p. 3793 - 3816

7
[ 163596-75-6 ]
[ 120077-69-2 ]

Reference： [1] Journal of the Chemical Society, 1927, p. 25

8
[ 1122-91-4 ]
[ 120077-69-2 ]

Reference： [1] Journal of the Chemical Society, 1927, p. 25

[ 120077-69-2 ] Synthesis Path-Downstream 1~14

1
[ 163596-75-6 ]
[ 120077-69-2 ]

Reference： [1]Journal of the Chemical Society,1927,p. 25

2
[ 120077-69-2 ]
[ 25118-59-6 ]

Reference： [1]Journal of the Chemical Society,1927,p. 25

3
[ 916520-49-5 ]
[ 61363-56-2 ]
[ 120077-69-2 ]
trans-10-(4-bromo-3-chlorophenyl)-1-ethyl-9,10-dihydro-1H,8H-2,7-dioxa-9-azaanthracene-4,5-dione [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 6869 - 6887

4
[ 372120-72-4 ]
[ 61363-56-2 ]
[ 120077-69-2 ]
[ 927670-47-1 ]

Reference： [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 6869 - 6887

5
[ 54167-77-0 ]
[ 61363-56-2 ]
[ 120077-69-2 ]
4-(4-bromo-3-chlorophenyl)-1-methyl-1,2,4,9-tetrahydropyrano[3,4-b]pyrazolo[4,3-e]pyridine-3,5(6H,8H)-dione [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 30 4-(4-bromo-3-chlorophenyl)-1-methyl-1,2,4,9-tetrahydropyrano[3,4-b]pyrazolo[4,3-e]pyridine-3,5(6H,8H)-dione 2H-Pyran-3,5(4H,6H)-dione (0.057 g, 05 mmol), 3-chloro4-bromo-benzaldehyde (0.11 g, 0.5 mmol), and 5-amino-1-methyl-1,2-dihydropyrazol-3-one (0.056g, 0.5 mmol) were processed as described in Example 26C to provide 0.145 g of the title compound. 1H NMR (300 MHz, DMSO-d6)6 3.5 (s, 3H), 4.0 (s, 2H), 4.52 (q, 2H), 4.92 (s, 1H), 7.03 (dt, 1H), 7.32(t, 1H), 7.6 (dd, 1H), 9.62 (s, 1H), 10.1 (s, 1H); MS (ESI-) m/z 410 (M+H:) Anal. calcd for C16H13N3BrClO3: C, 46.80;H,3.19; N, 10.23. Found: C, 46.77;H, 3.43; N, 10.27.

Reference： [1]Patent: US2002/7059,2002,A1

6
[ 79-37-8 ]
[ 120077-68-1 ]
[ 67-68-5 ]
[ 120077-69-2 ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine In dichloromethane; water	iv (iv) (iv) 4-Bromo-3-chlorobenzaldehyde To a stirred solution of oxalyl chloride (4 g.) in dichloromethane (20 ml.) at -60° was added, a solution of dimethyl sulphoxide (4.6 g.), in dichloromethane (10 ml.) over 10 minutes. This was stirred for 5 minutes. A solution of 4-bromo-3-chlorobenzyl alcohol (6.5 g.) in dichloromethane (12 ml.) was then added over 10 minutes. The mixture was stirred at -60° for 30 minutes. Triethylamine (15 g.) was added and the mixture stirred and allowed to warm to 20°. Water (100 ml.) and dichloromethane (100 ml.) were added and the organic layer separated. The organic layer was washed with hydrochloric acid (2N, 250 ml.), saturated sodium hydrogen carbonate solution (satd) (250 ml.), brine (100 ml.) and dried and evaporated to give an oil.

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC; UNIVERSITY OF CALIFORNIA - US5502073, 1996, A

7
[ 57418-97-0 ]
[ 120077-69-2 ]

Reference： [1]Journal of Medicinal Chemistry,2011,vol. 54,p. 3793 - 3816

8
[ 21803-75-8 ]
[ 120077-69-2 ]

Reference： [1]Journal of Medicinal Chemistry,2011,vol. 54,p. 3793 - 3816

9
[ 120077-69-2 ]
[ 1261614-16-7 ]

Yield	Reaction Conditions	Operation in experiment
68.2%	With (bis-(2-methoxyethyl)amino)sulfur trufluoride In tetrahydrofuran; ethanol; dichloromethane at 22℃; for 20h;	24 Intermediate 24: l-Bromo-2-chloro-4-(difluoromethyl)benzene Ethanol (0.053 mL, 0.91 mmol) was added to 4-bromo-3-chlorobenzaldehyde (1 g, 4.56 mmol) and Deoxo-Fluor(R) (50% in THF) (3.36 mL, 7.75 mmol) in DCM (20 mL) at 22°C. The resulting solution was stirred at 22 °C for 20 hours. The reaction mixture was quenched with saturated NaHC03 (100 mL), extracted with DCM (2 x 150 mL), the organic layer was dried over Na2S04, filtered and evaporated to afford a yellow liquid. The crude product was purified by flash alumina chromatography, elution gradient 1 to 5% EtOAc in isohexane. Pure fractions were evaporated to dryness to afford the title compound (0.750 g, 68.2 %) as a colourless liquid, containing 4.5% starting aldehyde by NMR. The product was used in subsequent reactions without further purification1H NMR (400 MHz, CDC13) 6.59 (1H, td), 7.23 - 7.29 (1H, m), 7.60 (1H, s), 7.72 (1H, d).

Reference： [1]Current Patent Assignee: ASTRAZENECA PLC - WO2011/121350, 2011, A1 Location in patent: Page/Page column 104

10
[ 25118-59-6 ]
[ 120077-69-2 ]

Reference： [1]Journal of Medicinal Chemistry,2012,vol. 55,p. 10572 - 10583
[2]Patent: WO2013/75083,2013,A1
[3]Patent: WO2014/8223,2014,A2
[4]Patent: US9206128,2015,B2
[5]Patent: WO2017/84630,2017,A1

11
[ 120077-68-1 ]
[ 120077-69-2 ]

Yield	Reaction Conditions	Operation in experiment
81%	With pyridinium chlorochromate In dichloromethane at 25℃; for 3h;	58.2 4-bromo-3-chlorobenzaldehyde . 4-bromo-3-chlorobenzaldehyde . A mixture of (4-bromo-3-chlorophenyl)methanol (2.0 g, 9.0 mmol), pyridinium chlorochromate (2912 mg, 13.5 mmol) in dichloromethane (50 mLO was stirred at 25°C for 3 hours. The mixture was concentrated to give a residue. The residue was purified by column chromatography (silica gel, petroleum ethe/ ethyl acetate = 1 : 1) to give 4-bromo-3-chlorobenzaldehyde as a white solid (1.6g g, 81%). 1H NMR (300 MHz, d6- DMSO): δ 9.96 (s, 1H), 7.69 (d, J=8.1,1H), δ 7.53 (d, J=0.9,1H), 7.19 (dd, Ji=8.1,lH J2=0.9, 1H)
81%	With pyridinium chlorochromate In dichloromethane at 25℃; for 3h;	58 4-bromo-3-chlorobenzaldehyde A mixture of (4-bromo-3-chlorophenyl)methanol (2.0 g, 9.0 mmol), pyridinium chlorochromate (2912 mg, 13.5 mmol) in dichloromethane (50 mL0 was stirred at 25° C. for 3 hours. The mixture was concentrated to give a residue. The residue was purified by column chromatography (silica gel, petroleum ethe/ethyl acetate=1:1) to give 4-bromo-3-chlorobenzaldehyde as a white solid (1.6 g g, 81%). 1H NMR (300 MHz, d6-DMSO): δ 9.96 (s, 1H), 7.69 (d, J=8.1, 1H), δ 7.53 (d, J=0.9, 1H), 7.19 (dd, J=8.1, 1H J2=0.9, 1H
46.6%	With manganese(IV) oxide In dichloromethane at 25℃; for 18h;	202.2 To a solution of (4-bromo-3-chlorophenyl)methanol (1.3 g, 5.87 mmol) in 1,2-dichloroethane (20 mL) at 25 °Cwas added manganese dioxide (5.1 g, 58.7 mmol), and stirred at 25 °C for 18 h. The mixture was filtered and the filtrate was concentrated underreduced pressure. The residue was purified by silica gel column (5-10% EtOAc in petroleum ether) to give 4-bromo-3-chlorobenzaldehyde (600 mg, 46.6% yield) as a light yellow oil.

38%	With pyridinium chlorochromate In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere;	37.b b) 4-bromo-3-chlorobenzaldehyde To a solution of (4-bromo-3-chlorophenyl)methanol (1.4 g, 6.32 mmol) in dichloromethane (15 mL) cooled to 0 °C in an ice bath was added pyridinium chlorochromate (2 g, 9.28 mmol) slowly and portion wise. The flask was placed under a nitrogen bubbler and stirred, allowing the ice bath to slowly warm to room temperature. After 2 h, 1H NMR analysis of an aliquot showed complete loss of methylene protons and the presence of the aldehyde proton. The reaction solution was filtered through Celite, the Celite plug was washed with dichloromethane (100 mL), and the filtrate was concentrated in vacuo. Purification via flash chromatography (0-30% ethyl acetate/hex anes) afforded the title compound (0.52 g, 38%). 1H NMR (400 MHz, CHLOROFORM- ) d ppm 7.65 (dd, J=8.21, 1.89 Hz, 1 H) 7.84 (d, J=8.08 Hz, 1 H) 7.97 (d, J=1.77 Hz, 1 H) 9.97 (s, 1 H).
1.6 g	With manganese(IV) oxide In dichloromethane at 20℃; for 120h;

Reference： [1]Current Patent Assignee: MORPHOSYS AG - WO2013/75083, 2013, A1 Location in patent: Paragraph 00409; 00411
[2]Current Patent Assignee: MORPHOSYS AG - US9206128, 2015, B2 Location in patent: Page/Page column 194; 195
[3]Current Patent Assignee: RQX PHARMACEUTICALS INC; ROCHE HOLDING AG - WO2017/84630, 2017, A1 Location in patent: Paragraph 00695
[4]Current Patent Assignee: GLAXOSMITHKLINE PLC - WO2014/8223, 2014, A2 Location in patent: Page/Page column 97
[5]Wijtmans, Maikel; Scholten, Danny J.; Roumen, Luc; Canals, Meritxell; Custers, Hans; Glas, Marjolein; Vreeker, Marlies C.A.; De Kanter, Frans J.J.; De Graaf, Chris; Smit, Martine J.; De Esch, Iwan J.P.; Leurs, Rob [Journal of Medicinal Chemistry, 2012, vol. 55, # 23, p. 10572 - 10583]

12
[ 1145-93-3 ]
[ 120077-69-2 ]
(E)-1-bromo-2-chloro-4-(4-methoxystyryl)benzene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
59%	With sodium methylate In methanol; N,N-dimethyl-formamide at 0 - 65℃; for 4h;	42 Example 42: Preparation of (E)_1-bromo-2-chloro-4-(4-methoxystyryl)benzene (C312) To a stirred solution of diethyl (4-methoxybenzyl)phosphonate (0.619 ml_, 2.73 mmol) in A/,N-dimethylformamide (3 ml.) at 0 °C was added a solution of sodium methoxide (5.4 M in methanol, 0.844 ml_, 4.56 mmol) . A solution of 4-bromo-3-chlorobenzaldehyde (0.5 g, 2.278 mmol) in Λ/,N-dimethylformamide ( 1 mL) was added, and the reaction mixture was heated to 65 °C for 4 hours. The reaction mixture was allowed to cool to room temperature and was partitioned between water and ethyl acetate. The organic layer was dried over magnesium sulfate, filtered, and concentrated. Purification by flash column chromatography using 0-10% ethyl acetate/hexanes as eluent provided the title compound as a yellow crystalline solid (0.484 g, 59% ) : mp 77 - 88 °C; N M R (400 MHz, CDCb) δ 7.58 - 7.53 (m, 2H), 7.47 - 7.39 ( m, 2H), 7.22 (dd, J = 8.4, 2.1 Hz, 1H), 7.06 (d, J = 16.2 Hz, 1H), 6.95 - 6.87 (m, 2H), 6.84 (d, J = 16.3 Hz, 1H), 3.84 (s, 3H) ; EIMS m/z 324.

Reference： [1]Current Patent Assignee: CORTEVA INC - WO2016/168059, 2016, A1 Location in patent: Page/Page column 287-288

13
[ 1030268-24-6 ]
[ 76469-88-0 ]
[ 120077-69-2 ]
methyl 4-(2-(4-bromo-2-chlorophenyl)-1-cyanocyclopropyl)benzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
49%		To a stirring solution of methyl 4-(cyanomethyl) benzoate (875 mg, 4.99 mmol) in dioxane (30 mL) was added 4-bromo-3-chlorobenzaldehyde (1.30 g, 5.92 mmol). Then t-BuOK (728 mg, 6.50 mmol) was added at -30C. After stirring for 0.5 h at room temperature, S, ^-dimethylmethanesulfinyl iodide (1.65 g, 7.50 mmol) was added at -30C. The resulting solution was stirred for another 3 h at room temperature. The reaction was then quenched by the addition of 150 mL of HCl (1 M). The resulting solution was extracted with 3x75 mL of ethyl acetate and the organic layers were combined and washed with water and brine, then dried over anhydrous magnesium sulfate and concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/hexane (1 :8). The collected fractions were combined and concentrated under vacuum. This resulted in 0.95 g (49%) of the title compound as a colorless solid.1HNMR (300 MHz, CDC13,ppm): delta 8.15-8.04 (m, 2H), 7.66 (d, J= 2.0 Hz, 1H), 7.55-7.42 (m, 3H), 7.16 (dd, J= 0.8, 8.3 Hz, 1H), 3.95 (s, 3H), 2.90 (t, J= 8.4 Hz, 1H), 2.30-2.26 (m, 1H), 2.17-2.12 (m, 1H).

Reference： [1]Patent: WO2018/75207,2018,A1 .Location in patent: Paragraph 0171

14
[ 444343-55-9 ]
[ 120077-69-2 ]
C₁₅H₂₀BrClO [ No CAS ]

Reference： [1]Chemical Science,2018,vol. 9,p. 8951 - 8956

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P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Ghs Hazard Statements

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere