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[ CAS No. 120347-74-2 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 120347-74-2
Chemical Structure| 120347-74-2
Structure of 120347-74-2 * Storage: {[proInfo.prStorage]}
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Product Details of [ 120347-74-2 ]

CAS No. :120347-74-2 MDL No. :MFCD13183907
Formula : C5H12BNO2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 128.97 Pubchem ID :-
Synonyms :

Safety of [ 120347-74-2 ]

Signal Word: Class:N/A
Precautionary Statements: UN#:N/A
Hazard Statements: Packing Group:N/A

Application In Synthesis of [ 120347-74-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 120347-74-2 ]

[ 120347-74-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 120347-74-2 ]
  • [ 6627-53-8 ]
  • [ 1383682-75-4 ]
YieldReaction ConditionsOperation in experiment
Stage #1: 5-piperidylboronic acid; 1-chloro-3-methoxy-4-nitrobenzene With sodium carbonate In 1,4-dioxane at 80℃; for 16h; Inert atmosphere; Stage #2: With sodium carbonate In 1,4-dioxane at 85℃; for 4h; 4-chloro-2-methoxy-nitrobenzene (2.0 g, 9.6 mmol) is taken up in 40 ml. anhydrous dioxane in an argon atmosphere. 3-pyridineboric acid (1.77 g, 14.4 mmol) is added to this mixture, followed by degassed sodium carbonate solution (10 ml_, 3 M) and bis- triphenylphosphine-palladium (II) chloride (337 mg, 48 mmol). The reaction mixture is stirred for 16 h at 80°C under an argon atmosphere. After further addition of sodium carbonate (3.2 g) and 0.1 eq palladium catalyst the mixture is stirred again for 4 h at 85 °C. After cooling, the reaction mixture is poured onto water (100 ml_), extracted 3 x with ethyl acetate (20 im L aliquots), the combined organic phases are dried on magnesium sulphate and evaporated down in vacuo. Chromatographic purification through silica gel with cyclohexane/ethyl acetate yields the coupling product.
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