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CAS No. : | 1206675-31-1 | MDL No. : | MFCD11042839 |
Formula : | C9H8F2O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 186.16 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | With thionyl chloride; In methanol; at 60℃; for 3h;Cooling with ice; | Step A: Preparation of 2,4-difluoro-3-methyl-benzoic acid methyl ester To a suspension of <strong>[112857-68-8]2,4-difluoro-3-methylbenzoic acid</strong> (950 mg, 5.52 mmol) in methanol (10 mL), cooled using an ice water bath, was added thionyl chloride (1 mL) in a dropwise manner. The solution was heated at 60 C. for three hours. The reaction was returned to ambient temperature and was concentrated in vacuo. The residue was partitioned between ethyl acetate and water. The organic layer was washed with water and brine and dried over magnesium sulfate. The slurry was filtered and concentrated to provide the ethyl ester as a yellow oil (1.1 g, 90%). MS (M+H): 187 |