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CAS No. : | 1214337-82-2 | MDL No. : | MFCD14698341 |
Formula : | C9H10BrNO3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 260.09 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | toluene-4-sulfonic acid; for 48h;Reflux; | Step 3. Synthesis of ethyl 5-bromo-6-methoxypyridine-2-carboxylate (C16). para-Toluenesulfonic acid hydrate (roughly 0.3 g) was added to a solution of 5- bromo-6-methoxypyridine-2-carboxylic acid (C15) (12.2 g, 52.6 mmol) in ethanol (300 mL). The reaction mixture was heated at reflux for 48 hours, then concentrated in vacuo to provide the title product. Yield: 13.5 g, 51 .9 mmol, 99%. |
97% | With chloro-trimethyl-silane; at 20℃; for 2h; | To a solution of <strong>[1214334-70-9]5-bromo-6-methoxypicolinic acid</strong> (1.03 g, 4.42 mmol) in ethanol (25 mL) trimethylsilyl chloride (3.84 g, 35.3 mmol) was added. The mixture was stirred at rt for 2 h before it was concentrated. The remaining residue was taken up in sat. aq. NaHCO3 solution and extracted three times with EA. The combined organic extracts were dried over MgSO4, filtered and concentrated and dried to give ethyl 5-bromo-6-methoxypicolinate 42 (1.12 g, 97%) as a white solid |