Home Cart 0 Sign in  

[ CAS No. 123637-77-4 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 123637-77-4
Chemical Structure| 123637-77-4
Structure of 123637-77-4 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 123637-77-4 ]

Related Doc. of [ 123637-77-4 ]

Alternatived Products of [ 123637-77-4 ]

Product Details of [ 123637-77-4 ]

CAS No. :123637-77-4 MDL No. :
Formula : C10H7BrClN Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 256.53 Pubchem ID :-
Synonyms :

Safety of [ 123637-77-4 ]

Signal Word: Class:
Precautionary Statements: UN#:
Hazard Statements: Packing Group:

Application In Synthesis of [ 123637-77-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 123637-77-4 ]
  • Downstream synthetic route of [ 123637-77-4 ]

[ 123637-77-4 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 123637-77-4 ]
  • [ 791626-59-0 ]
YieldReaction ConditionsOperation in experiment
92%
Stage #1: With hexamethylenetetramine In ethanol; water for 1 h; Heating / reflux
Stage #2: With hydrogenchloride; water In ethanol at 20℃; for 0.583333 h; Heating / reflux
The 1 :8 mixture of brominated quino lines 7.5 (3 g, 9.24 mmol, 1 equiv) and hexamethylenetetramine (3.89 g, 28 mmol, 3 equiv) were heated to reflux in 50percent aqueous ethanol (16 mL) for 1 h. After cooling to RT, water (10 mL) was added followed by the slow addition of 12N HCl (1.50 mL) over 5 min. The reaction mixture was heated to reflux for 0.5 h then cooled to RT. The reaction mixture was added to brine and extracted with DCM 4X. The collected organics were washed with brine 2X, dried (Na2SO4), filtered, and <n="101"/>concentrated. The solid was dried in vacuo to yield 2-chloro-quinoline-6-carbaldehyde 7.6 (1.63 g, 92percent) as a white solid which was used without further purification. MS: 192.00 (M+H+); 1H-NMR (DMSO-d6): .pound.(ppm) 10.17 (s, IH), 8.69 (m, IH), 8.68 (d, IH, J = 8.4 Hz), 8.21 (dd, IH, J = 9.0 Hz and 1.8 Hz), 8.09 (dd, IH, J = 8.4 Hz and 0.60 Hz), 7.75 (d, IH, J = 8.4 Hz).
Reference: [1] Patent: WO2008/8912, 2008, A1, . Location in patent: Page/Page column 87; 99-100
Same Skeleton Products
Historical Records