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[ CAS No. 124704-01-4 ] {[proInfo.proName]}

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Chemical Structure| 124704-01-4
Chemical Structure| 124704-01-4
Structure of 124704-01-4 * Storage: {[proInfo.prStorage]}
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Product Details of [ 124704-01-4 ]

CAS No. :124704-01-4 MDL No. :MFCD00751599
Formula : C11H13F2NO Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 213.22 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 124704-01-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 124704-01-4 ]

[ 124704-01-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 124704-01-4 ]
  • [ 130345-50-5 ]
  • [ 1428663-52-8 ]
YieldReaction ConditionsOperation in experiment
50.7% [0186] To a solution of N-(2,4-difluorophenyl)pivalamide (740 mg, 3.46 mmol, 1.2 eq.) in THF (10 mL) cooled at -78 C was added n-BuLi (2.76 mL, 6.9 mmol, 2.4 eq.) dropwise. The resulting mixture was stirred at -78 C for 1 h, then a solution of <strong>[130345-50-5]quinoxaline-6-carbaldehyde</strong> (450 mg, 2.88 mmol, 1.0 eq.) in THF (20 mL) was added dropwise. The mixture was stirred at -78 C for lh, then quenched by the addition of NH4C1 solution. The mixture was extracted with EA (20 mL X 3) and the combined organic layers were dried over Na2S04 and concentrated. The resulting residue was purified via flash column chromatography (PE/EA=2/1, v/v) to afford N-(2,4-difluoro-3-(hydroxy(quinoxalin- 6-yl)methyl)phenyl)pivalamide as a yellow foam (541 mg, 50.7%).
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