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at 230℃; for 1 h; Inert atmosphere; Sealed tube; Microwave irradiation
c) 5 -bromo-7-fluoro- 1 -benzofuranA solution of 5-bromo-7-fluoro-l-benzofuran-2-carboxylic acid (1.274 mmol) in quinoline (2 mL) was treated with copper dust (0.236 mmol). The reaction was purged with nitrogen, sealed and irradiated in a microwave reactor at 230 °C for 60 min. The solution was diluted with ethyl acetate and was filtered through Celite. The filtrate was concentrated in vacuo, and the residue was purified by flash chromatography (hexanes) to provide the title compound as a clear oil (280 mg, 100percent yield). 1H NMR (400 MHz,DMSO-de) δ ppm 8.17 (d, J=2.02 Hz, 1 H) 7.77 (d, J=1.77 Hz, 1 H) 7.55 (dd, J=10.48, 1.64 Hz, 1 H) 7.07 (dd, J=3.16, 2.15 Hz, 1 H).
copper; at 230℃; for 1.0h;Inert atmosphere; Sealed tube; Microwave irradiation;
c) 5 -bromo-7-fluoro- 1 -benzofuranA solution of 5-bromo-7-fluoro-l-benzofuran-2-carboxylic acid (1.274 mmol) in quinoline (2 mL) was treated with copper dust (0.236 mmol). The reaction was purged with nitrogen, sealed and irradiated in a microwave reactor at 230 C for 60 min. The solution was diluted with ethyl acetate and was filtered through Celite. The filtrate was concentrated in vacuo, and the residue was purified by flash chromatography (hexanes) to provide the title compound as a clear oil (280 mg, 100% yield). 1H NMR (400 MHz,DMSO-de) delta ppm 8.17 (d, J=2.02 Hz, 1 H) 7.77 (d, J=1.77 Hz, 1 H) 7.55 (dd, J=10.48, 1.64 Hz, 1 H) 7.07 (dd, J=3.16, 2.15 Hz, 1 H).