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CAS No. : | 1258226-87-7 | MDL No. : | MFCD28386270 |
Formula : | C50H67N7O8 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | PIDFDZJZLOTZTM-KHVQSSSXSA-N |
M.W : | 894.11 | Pubchem ID : | 54767916 |
Synonyms : |
ABT-267
|
Chemical Name : | Methyl ((S)-1-((S)-2-((4-((2S,5S)-1-(4-(tert-butyl)phenyl)-5-(4-((S)-1-((methoxycarbonyl)-L-valyl)pyrrolidine-2-carboxamido)phenyl)pyrrolidin-2-yl)phenyl)carbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
2.3 g | With triethylamine; HATU; In N,N-dimethyl-formamide; at 20℃; for 1.5h; | To a solution of 4,4'-((2S,5S)-l-(4-tert-butylphenyl)pyrrolidine-2,5-diyl)dianiline (0058) (1.64 g, 4.25 mmol) in DMF (20 ml), (S)-l-((S)-2-(methoxycarbonylamino)-3- methylbutanoyl)pyrrolidine-2-carboxylic acid (2.89 g, 10.63 mmol), and HATU (4.04 g, 10.63 mmol) in DMF (150mL) was added triethylamine (1.07 g, 10.63 mmol), and the solution was stirred at room temperature for 90 min. To the reaction mixture was poured 20 mL of water, and the white precipitate obtained was filtered, and the solid was washed with water (3x5 mL). The solid was blow dried for lh. The crude material was loaded on a silica gel column and eluted with a gradient starting with ethyl acetate/ heptane (3/7), and ending with pure ethyl acetate. The desired fractions were combined and solvent distilled off to give a very light yellow solid, which was dried at 45 C in a vacuum oven with nitrogen purge for 15 h to give Compound I (2.3 g, 61% yield). |