Alternatived Products of [ 1260795-26-3 ]
Product Details of [ 1260795-26-3 ]
CAS No. : | 1260795-26-3 |
MDL No. : | |
Formula : |
C9H7BrN2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
223.07
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 1260795-26-3 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 1260795-26-3 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1260795-26-3 ]
- 1
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[ 1150271-23-0 ]
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[ 244205-40-1 ]
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[ 1260795-26-3 ]
Yield | Reaction Conditions | Operation in experiment |
26% |
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,4-dioxane; water; at 110℃;Inert atmosphere; |
2-Bromophenylboronic acid, 6.00 g (29.9 mmol), tert-butyl 4-bromo-1H-pyrazole-1 - carboxylate, 3.69 g (14.9 mmol), potassium carbonate, 8.26 g (59.8 mmol), and tetrakis(triphenylphosphine) palladium(O), 1.22 g (1.5 mmol), were added into 60 ml. of 1,4- dioxane/water (5:1, v:v). The resulting mixture was stirred at 1 10C for overnight under nitrogen atmosphere. After cooled to room temperature, water was added and the resulting mixture was extracted with ethyl acetate and the combined organic layers were dried over anhydrous sodium sulfate. The solvent was removed in vacuo and the residue was purified by silica gel column chromatography to give 2.00 g (26%) of the product as a light yellow solid. MS (ESIpos): m/z = 223 [M+H]+. LC-MS [method 4, gradient starting with water (0.05%TFA)-Acetonitrile, 5%B]: Rt = 0.96 min. |