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[ CAS No. 1261570-38-0 ] {[proInfo.proName]}

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Chemical Structure| 1261570-38-0
Chemical Structure| 1261570-38-0
Structure of 1261570-38-0 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1261570-38-0 ]

CAS No. :1261570-38-0 MDL No. :MFCD18395960
Formula : C11H13BrO3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 273.12 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 1261570-38-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1261570-38-0 ]

[ 1261570-38-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1261570-38-0 ]
  • [ 598-55-0 ]
  • ethyl 2-(2-methoxy-4-(methoxycarbonylamino)phenyl)acetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
61.6% With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; XPhos In toluene at 90℃; for 19h; Inert atmosphere; 1 Step-1: Preparation of ethyl 2-(2-methoxy-4-(methoxycarbonylamino)phenyl)acetate (19b) To a degassed solution of ethyl 2-(4-bromo-2-methoxyphenyl)acetate (19a) (750 mg, 2.75 mmol; CAS1261570-38-0) in toluene (30 mL) was added dicyclohexyl(2',4',6'- triisopropylbiphenyl-2-yl)phosphine (131 mg, 0.275 mmol), methyl carbamate (309 mg, 4.12 mmol), Pd2(dba)3 (126 mg, 0.137 mmol), cesium carbonate (895 mg, 2.75 mmol) and heated under nitrogen at 90 °C for 19 h. The reaction mixture was diluted with ethyl acetate (100 mL), washed with water (60 mL), brine (60 mL), dried, filtered and concentrated in vacuum. The residue obtained was purified by flash column chromatography (silica gel (24g), eluting with 0 to 25% ethyl acetate in hexanes) to give ethyl 2-(2-methoxy-4- (methoxycarbonylamino)phenyl)acetate (19b) (452 mg, 61.6 % yield) as a yellow solid; NMR (300 MHz, DMSO-7e) d 9.62 (s, 1H), 7.20 - 7.17 (m, 1H), 7.05 (d, J= 8.1 Hz, 1H), 6.94 (dd, J= 8.1, 2.0 Hz, 1H), 4.04 (q, 7= 7.1 Hz, 2H), 3.70 (s, 3H), 3.66 (s, 3H), 3.49 (s, 2H), 1.16 (t, J= 7.1 Hz, 3H); MS (ES+): 268.1 (M+l)
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