Alternatived Products of [ 1269646-23-2 ]
Product Details of [ 1269646-23-2 ]
CAS No. : | 1269646-23-2 |
MDL No. : | N/A |
Formula : |
C21H33BN2O3Si
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
400.39
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 1269646-23-2 ]
Application In Synthesis of [ 1269646-23-2 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1269646-23-2 ]
- 1
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[ 176961-53-8 ]
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[ 1269646-23-2 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C
1.2: 24 h / 0 - 20 °C
2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; (diphenylphosphin)ferrocene / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere |
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Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
1.2: 2 h / 20 °C
2.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere |
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Reference:
[1]Current Patent Assignee: PFIZER INC - WO2011/29027, 2011, A1
[2]Riggs, Jennifer R.; Nagy, Mark; Elsner, Jan; Erdman, Paul; Cashion, Dan; Robinson, Dale; Harris, Roy; Huang, Dehua; Tehrani, Lida; Deyanat-Yazdi, Gordafaried; Narla, Rama Krishna; Peng, Xiaohui; Tran, Tam; Barnes, Leo; Miller, Terra; Katz, Jason; Tang, Yang; Chen, Ming; Moghaddam, Mehran F.; Bahmanyar, Sogole; Pagarigan, Barbra; Delker, Silvia; Lebrun, Laurie; Chamberlain, Philip P.; Calabrese, Andrew; Canan, Stacie S.; Leftheris, Katerina; Zhu, Dan; Boylan, John F.
[Journal of Medicinal Chemistry, 2017, vol. 60, # 21, p. 8989 - 9002]
- 2
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[ 76513-69-4 ]
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[ 176961-53-8 ]
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[ 1269646-23-2 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere
1.2: 3 h / 20 °C / Inert atmosphere
2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 2 h / 100 °C |
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