Alternatived Products of [ 1307248-40-3 ]
Product Details of [ 1307248-40-3 ]
CAS No. : | 1307248-40-3 |
MDL No. : | MFCD22381013 |
Formula : |
C13H16F3NO3S
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
323.33
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 1307248-40-3 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 1307248-40-3 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 1307248-40-3 ]
- Downstream synthetic route of [ 1307248-40-3 ]
- 1
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[ 1307248-40-3 ]
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[ 1307245-86-8 ]
- 2
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[ 1307248-40-3 ]
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[ 1307248-45-8 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 4 steps
1: sodium hydroxide; water / dichloromethane / Cooling with ice
2: 2-methyltetrahydrofuran / 22 °C
3: acetic acid; sulfuryl dichloride / tert-butyl methyl ether / 21.17 h / 15 - 22 °C
4: triethylamine / dmap / dichloromethane / 20 °C |
|
|
Multi-step reaction with 3 steps
1: sodium hydroxide / dichloromethane; water / Cooling with ice
2: acetic acid; sulfuryl dichloride / tert-butyl methyl ether / 21.17 h / 15 - 22 °C
3: dmap; triethylamine / dichloromethane / 20 °C |
|
- 3
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[ 1307248-40-3 ]
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[ 1283095-48-6 ]
- 4
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[ 1307248-40-3 ]
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[ 16271-33-3 ]
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1-((2,4-dichlorophenyl)sulfonyl)-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
67% |
With triethylamine; In N,N-dimethyl-formamide; at 20℃; for 5h; |
General procedure: To a solution of 40,50-dihydrospiro[piperidine-4,70-thieno[2,3-c]pyran]-1-ium trifluoroacetate (03) (200 mg, 0.62 mmol) in DMF(5 mL) was added triethylamine (187 mg, 1.86 mmol) followedby benzene sulfonylchloride (0.685 mmol) at ambient temperature.The reaction mixture was stirred for 5 h at room temperature.When TLC showed complete consumption of starting material, thereaction mixture was poured on ice-cold water under stirring andthen filtered, washed with water, dried under vacuum at 60 C for2 h. The crude product was triturated with tert-butylmethyl etherto obtain pure corresponding substituted 1-(phenylsulfonyl)-40,50-dihydrospiro[piperidine-4,70-thieno[2,3-c]pyran] (04-10) ingood yield. |
- 5
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[ 1307248-40-3 ]
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[ 72482-64-5 ]
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(2,4-difluorophenyl)(4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)methanone
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
39% |
With triethylamine; In N,N-dimethyl-formamide; at 20℃; for 5h; |
General procedure: To a solution of 4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-ium trifluoroacetate (03) (200 mg, 0.62 mmol) in DMF(5 mL) was added triethylamine (187 mg, 1.86 mmol) followedby various benzoyl chlorides at ambient temperature. The reactionmixture was stirred for 5 h at room temperature. When TLCshowed complete consumption of starting material, the reactionmixture was poured on ice-cold water under stirring and then filtered,washed with water, dried under vacuum at 60 C for 1 h. Thecrude product was triturated with tert-butylmethyl ether to obtaincorresponding substituted (4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)(phenyl)methanone (11-17) in goodyield. |