Alternatived Products of [ 133455-10-4 ]
Product Details of [ 133455-10-4 ]
CAS No. : | 133455-10-4 |
MDL No. : | MFCD08166652 |
Formula : |
C12H15N3
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
201.27
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 133455-10-4 ]
Application In Synthesis of [ 133455-10-4 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 133455-10-4 ]
- Downstream synthetic route of [ 133455-10-4 ]
- 1
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[ 133455-10-4 ]
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[ 58113-30-7 ]
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[ 584-08-7 ]
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1-[4-[3-[4-(1H-indazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
With Ki In acetonitrile |
14 1-[4-[3-[4-(1H-Indazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone
EXAMPLE 14 1-[4-[3-[4-(1H-Indazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone A mixture of 3-(4-piperidinyl)-1H-indazole (3.0 g, 15 mmol), K2 CO3 (1.6 g), 1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanone (5.3 g, 22 mmol), a few crystals of KI and acetonitrile (100 ml) was stirred and refluxed for 16 hours. The reaction was poured into water and a white solid separated from solution. The solid was collected, dried and afforded 5.1 g of product. Recrystallization from ethanol yielded 3.6 g of the compound, which upon chromatography (preparative HPLC on silica gel, eluding with methylene chloride/methanol-9:1) gave 3.0 g (49%) of an off-white solid. Recrystallization from ethanol afforded the analytically pure 1-[4-[3-[4-(1H-indazol-3-yl)-1-piperidinyl]-propoxy]-3-methoxyphenyl]ethanone as a white solid, m.p.=171°-173° C. ANALYSIS: Calculated for C24 H29 N3 O3: 70.74%C, 7.17%H, 10.31%N; Found: 70.52%C, 7.27%H, 10.42%N. |
- 2
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[ 133455-10-4 ]
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[ 58113-30-7 ]
-
[ 584-08-7 ]
-
1-[4-[3-[4-(1H-indazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone
[ No CAS ]
-
1-[4-[3-[4-(1H-Indazol-3-yl)-1-giperidinl]propoxy]-3-methoxhenyl]ethanone
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
With Ki In acetonitrile |
14 1-[4-[3-[4-(1H-Indazol-3-yl)-1-giperidinl]propoxy]-3-methoxhenyl]ethanone
EXAMPLE 14 1-[4-[3-[4-(1H-Indazol-3-yl)-1-giperidinl]propoxy]-3-methoxhenyl]ethanone A mixture of 3-(4-piperidinyl)-1H-indazole (3.0 g, 15 mmol), K2 CO3 (1.6 g), 1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanone (5.3 g, 22 mmol), a few crystals of KI and acetonitrile (100 ml) was stirred and refluxed for 16 hours. The reaction was poured into water and a white solid separated from solution. The solid was collected, dried and afforded 5.1 g of product. Recrystallization from ethanol yielded 3.6 g of the compound, which upon chromatography (preparative HPLC on silica gel, eluding with methylene chloride/methanol-9:1) gave 3.0 g (49%) of an off-white solid. Recrystallization from ethanol afforded the analytically pure 1-[4-[3-[4-(1H-indazol-3-yl)-1-piperidinyl]-propoxy]-3-methoxyphenyl]ethanone as a white solid, m.p.=171°-173° C. ANALYSIS: Calculated for C24 H29 N3 O3: 70.74%C 7.17%H 10.31%N; Found: 70.52%C 7.27%H 10.42%N |