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[ CAS No. 133728-31-1 ]

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Chemical Structure| 133728-31-1
Chemical Structure| 133728-31-1
Structure of 133728-31-1 * Storage: {[proInfo.prStorage]}

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Product Details of [ 133728-31-1 ]

CAS No. :133728-31-1 MDL No. :MFCD20483323
Formula : C9H11NO3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :181.19 g/mol Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 133728-31-1 ]

  • Downstream synthetic route of [ 133728-31-1 ]

[ 133728-31-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 5372-81-6 ]
  • [ 133728-31-1 ]
YieldReaction ConditionsOperation in experiment
39% With diisobutylaluminium hydride In tetrahydrofuran; diethyl ether at -78 - 0℃; for 4h;
33% With diisobutylaluminium hydride In tetrahydrofuran; diethyl ether at -78 - 20℃; 9 The reactant f was dissolved in tertahydrofuran/diethyl ether (2: 1) and treated with DIBAL-H at -78 0C before warming to 0 0C and stirred for further 4 h. The mixture was stirred at room temperature overnight, followed by routine workup to afford the desired product g (33%).
With lithium triethylborohydride In tetrahydrofuran at -78℃;
With sodium borohydrid In methanol; <i>tert</i>-butyl alcohol 1.b b) b) Methyl 2-amino-4-hydroxymethyl-benzoate 10.5 g (0.05 mol) of dimethyl 2-aminoterephthalate are suspended in 150 ml of tert.butanol, 5.7 g (0.15 mol) of sodium borohydride are added and the mixture is heated to 85°. After stirring for 1 hour at this temperature, 15 ml of methanol are gradually added dropwise with simultaneous refluxing. Then the reaction mixture is boiled for a further hour, with stirring, then cooled and extracted three times with 50 ml of saturated saline solution. The butanol is distilled off in vacuo and the residue is recrystallized from ethyl acetate. 6-7 g of the desired amino alcohol are obtained in the form of white crystals, m.p. 102°-103° C., which contain only a little of the isomeric carbinol. 1 H-NMR (CD3 OD):δ=7.72(1H,d,J=7.0Hz,); 6.73(1H,d,J=2Hz, Hm); 6.52(1H,dd,J=7.0, 2.0Hz,); 4.50 (2H,s,CH2 --O); 3.80 (3H,s,OCH3); NH2, OH in the solvent blind peak.

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